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Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

OBJECTIVE: Chronic fibrosing liver injury is a major risk factor for hepatocarcinogenesis in humans. Mice with targeted deletion of Mdr2 (the murine ortholog of MDR3) develop chronic fibrosing liver injury. Hepatocellular carcinoma (HCC) emerges spontaneously in such mice by 50–60 weeks of age, prov...

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Detalles Bibliográficos
Autores principales:	Philips, George M., Chan, Isaac S., Swiderska, Marzena, Schroder, Vanessa T., Guy, Cynthia, Karaca, Gamze F., Moylan, Cynthia, Venkatraman, Talaignair, Feuerlein, Sebastian, Syn, Wing-Kin, Jung, Youngmi, Witek, Rafal P., Choi, Steve, Michelotti, Gregory A., Rangwala, Fatima, Merkle, Elmar, Lascola, Christopher, Diehl, Anna Mae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166282/ https://www.ncbi.nlm.nih.gov/pubmed/21912653 http://dx.doi.org/10.1371/journal.pone.0023943

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