Cargando…

Studies of Metabolic Phenotypic Correlates of 15 Obesity Associated Gene Variants

AIMS: Genome-wide association studies have identified novel BMI/obesity associated susceptibility loci. The purpose of this study is to determine associations with overweight, obesity, morbid obesity and/or general adiposity in a Danish population. Moreover, we want to investigate if these loci asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sandholt, Camilla Helene, Vestmar, Marie Aare, Bille, Dorthe Sadowa, Borglykke, Anders, Almind, Katrine, Hansen, Lars, Sandbæk, Annelli, Lauritzen, Torsten, Witte, Daniel, Jørgensen, Torben, Pedersen, Oluf, Hansen, Torben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166286/ https://www.ncbi.nlm.nih.gov/pubmed/21912638 http://dx.doi.org/10.1371/journal.pone.0023531

Ejemplares similares

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
por: Andreasen, Camilla Helene, et al.
Publicado: (2008)

Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes
por: Andreasen, Camilla Helene, et al.
Publicado: (2009)

Implications of Central Obesity-Related Variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on Quantitative Metabolic Traits in Adult Danes
por: Bille, Dorthe S., et al.
Publicado: (2011)

Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes
por: Andreasen, Camilla H., et al.
Publicado: (2008)

Combined Analyses of 20 Common Obesity Susceptibility Variants
por: Sandholt, Camilla Helene, et al.
Publicado: (2010)

The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals
por: Banasik, Karina, et al.
Publicado: (2012)

The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load
por: Hornbak, Malene, et al.
Publicado: (2011)

Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
por: Burgdorf, Kristoffer Sølvsten, et al.
Publicado: (2011)

Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes
por: Zobel, Dorit P., et al.
Publicado: (2009)

A Combined Analysis of 48 Type 2 Diabetes Genetic Risk Variants Shows No Discriminative Value to Predict Time to First Prescription of a Glucose Lowering Drug in Danish Patients with Screen Detected Type 2 Diabetes
por: Hornbak, Malene, et al.
Publicado: (2014)

Bioinformatics-Driven Identification and Examination of Candidate Genes for Non-Alcoholic Fatty Liver Disease
por: Banasik, Karina, et al.
Publicado: (2011)

The Effect of PCSK1 Variants on Waist, Waist-Hip Ratio and Glucose Metabolism Is Modified by Sex and Glucose Tolerance Status
por: Gjesing, Anette P., et al.
Publicado: (2011)

Correction: Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants
por: Borglykke, Anders, et al.
Publicado: (2013)

Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants
por: Borglykke, Anders, et al.
Publicado: (2012)

Genetic Risk Score of 46 Type 2 Diabetes Risk Variants Associates With Changes in Plasma Glucose and Estimates of Pancreatic β-Cell Function Over 5 Years of Follow-Up
por: Andersson, Ehm A., et al.
Publicado: (2013)

Natural Selection Affects Multiple Aspects of Genetic Variation at Putatively Neutral Sites across the Human Genome
por: Lohmueller, Kirk E., et al.
Publicado: (2011)

The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation
por: Krarup, Nikolaj Thure, et al.
Publicado: (2012)

The Type 2 Diabetes Associated Minor Allele of rs2237895 KCNQ1 Associates with Reduced Insulin Release Following an Oral Glucose Load
por: Holmkvist, Johan, et al.
Publicado: (2009)

Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes
por: Hansen, Tue H, et al.
Publicado: (2015)

Correction: The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation
por: Krarup, Nikolaj Thure, et al.
Publicado: (2012)

Do Gene Variants Influencing Adult Adiposity Affect Birth Weight? A Population-Based Study of 24 Loci in 4,744 Danish Individuals
por: Andersson, Ehm A., et al.
Publicado: (2010)

Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders
por: Andersen, Mette Korre, et al.
Publicado: (2016)

Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes
por: Gjesing, Anette P, et al.
Publicado: (2011)

Validity of Danish register diagnoses of myocardial infarction and stroke against experts in people with screen-detected diabetes
por: Dalsgaard, Else-Marie, et al.
Publicado: (2019)

Higher Physical Activity Is Associated With Lower Aortic Stiffness but Not With Central Blood Pressure: The ADDITION-Pro Study
por: Laursen, Anne Sofie Dam, et al.
Publicado: (2015)

Prevalence of Neuropathy and Peripheral Arterial Disease and the Impact of Treatment in People With Screen-Detected Type 2 Diabetes: The ADDITION-Denmark study
por: Charles, Morten, et al.
Publicado: (2011)

Associations between Ultrasound Measures of Abdominal Fat Distribution and Indices of Glucose Metabolism in a Population at High Risk of Type 2 Diabetes: The ADDITION-PRO Study
por: Philipsen, Annelotte, et al.
Publicado: (2015)

Does training of general practitioners for intensive treatment of people with screen-detected diabetes have a spillover effect on mortality and cardiovascular morbidity in ‘at risk’ individuals with normoglycaemia? Results from the ADDITION-Denmark cluster-randomised controlled trial
por: Simmons, Rebecca K., et al.
Publicado: (2017)

Prevalence of sexual desire and satisfaction among patients with screen-detected diabetes and impact of intensive multifactorial treatment: Results from the ADDITION-Denmark study
por: Pedersen, Mette B., et al.
Publicado: (2015)

Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care
por: Johansen, Nanna B, et al.
Publicado: (2012)

Lifting the lid of the "black intervention box" - the systematic development of an action competence programme for people with screen-detected dysglycaemia
por: Maindal, Helle Terkildsen, et al.
Publicado: (2010)

Variation in CHI3LI in Relation to Type 2 Diabetes and Related Quantitative Traits
por: Rathcke, Camilla Noelle, et al.
Publicado: (2009)

Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle
por: Ribel-Madsen, Rasmus, et al.
Publicado: (2010)

Role of fasting duration and weekday in incretin and glucose regulation
por: Clemmensen, Kim K B, et al.
Publicado: (2020)

Role of fasting duration and weekday in incretin and glucose regulation
por: Clemmensen, Kim K B, et al.
Publicado: (2021)

Effect of screening for type 2 diabetes on risk of cardiovascular disease and mortality: a controlled trial among 139,075 individuals diagnosed with diabetes in Denmark between 2001 and 2009
por: Simmons, Rebecca K., et al.
Publicado: (2017)

Effect of population screening for type 2 diabetes and cardiovascular risk factors on mortality rate and cardiovascular events: a controlled trial among 1,912,392 Danish adults
por: Simmons, Rebecca K., et al.
Publicado: (2017)

Lung function in adults and future burden of obstructive lung diseases in a long-term follow-up
por: Ørts, Lene Maria, et al.
Publicado: (2020)

Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures
por: Lundgren, Julie R., et al.
Publicado: (2019)

Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men
por: Janus, Charlotte, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3idpr37esbfr44l7u4km3l0ong