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Improving Antigenicity of the Recombinant Hepatitis C Virus Core Protein via Random Mutagenesis

In order to enhance the sensitivity of diagnosis, a recombinant clone containing domain I of HCV core (amino acid residues 1 to 123) was subjected to random mutagenesis. Five mutants with higher sensitivity were obtained by colony screening of 616 mutants using reverse ELISA. Sequence analysis of th...

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Detalles Bibliográficos
Autores principales:	Huang, Chen-Ji, Peng, Hwei-Ling, Cheng, Chih-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166572/ https://www.ncbi.nlm.nih.gov/pubmed/21904443 http://dx.doi.org/10.1155/2011/359042

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