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Signalling pathways underlying structural plasticity of dendritic spines

Synaptic plasticity, or changes in synaptic strength, is thought to underlie learning and memory. Imaging studies, mainly in brain slices, have revealed that long-term synaptic plasticity of excitatory synapses in hippocampal neurons is coupled with structural plasticity of dendritic spines, which i...

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Detalles Bibliográficos
Autores principales: Patterson, Michael, Yasuda, Ryohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166652/
https://www.ncbi.nlm.nih.gov/pubmed/21410464
http://dx.doi.org/10.1111/j.1476-5381.2011.01328.x
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author Patterson, Michael
Yasuda, Ryohei
author_facet Patterson, Michael
Yasuda, Ryohei
author_sort Patterson, Michael
collection PubMed
description Synaptic plasticity, or changes in synaptic strength, is thought to underlie learning and memory. Imaging studies, mainly in brain slices, have revealed that long-term synaptic plasticity of excitatory synapses in hippocampal neurons is coupled with structural plasticity of dendritic spines, which is thought to be essential for inducing and regulating functional plasticity. Using pharmacological and genetic manipulation, the signalling network underlying structural plasticity has been extensively studied. Furthermore, the recent advent of fluorescence resonance energy transfer (FRET) imaging techniques has provided a readout of the dynamics of signal transduction in dendritic spines undergoing structural plasticity. These studies reveal the signalling pathways relaying Ca(2+) to the functional and structural plasticity of dendritic spines. LINKED ARTICLES: This article is part of a themed section on Imaging. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2011.163.issue-8BJP has previously published an Imaging in Pharmacology themed section, edited by A Davenport and C Daly. To view this section visit http://dx.doi.org/10.1111/bph.2010.159.issue-4
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spelling pubmed-31666522011-09-06 Signalling pathways underlying structural plasticity of dendritic spines Patterson, Michael Yasuda, Ryohei Br J Pharmacol Themed Section: Reviews Synaptic plasticity, or changes in synaptic strength, is thought to underlie learning and memory. Imaging studies, mainly in brain slices, have revealed that long-term synaptic plasticity of excitatory synapses in hippocampal neurons is coupled with structural plasticity of dendritic spines, which is thought to be essential for inducing and regulating functional plasticity. Using pharmacological and genetic manipulation, the signalling network underlying structural plasticity has been extensively studied. Furthermore, the recent advent of fluorescence resonance energy transfer (FRET) imaging techniques has provided a readout of the dynamics of signal transduction in dendritic spines undergoing structural plasticity. These studies reveal the signalling pathways relaying Ca(2+) to the functional and structural plasticity of dendritic spines. LINKED ARTICLES: This article is part of a themed section on Imaging. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2011.163.issue-8BJP has previously published an Imaging in Pharmacology themed section, edited by A Davenport and C Daly. To view this section visit http://dx.doi.org/10.1111/bph.2010.159.issue-4 Blackwell Publishing Ltd 2011-08 /pmc/articles/PMC3166652/ /pubmed/21410464 http://dx.doi.org/10.1111/j.1476-5381.2011.01328.x Text en British Journal of Pharmacology © 2011 The British Pharmacological Society
spellingShingle Themed Section: Reviews
Patterson, Michael
Yasuda, Ryohei
Signalling pathways underlying structural plasticity of dendritic spines
title Signalling pathways underlying structural plasticity of dendritic spines
title_full Signalling pathways underlying structural plasticity of dendritic spines
title_fullStr Signalling pathways underlying structural plasticity of dendritic spines
title_full_unstemmed Signalling pathways underlying structural plasticity of dendritic spines
title_short Signalling pathways underlying structural plasticity of dendritic spines
title_sort signalling pathways underlying structural plasticity of dendritic spines
topic Themed Section: Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166652/
https://www.ncbi.nlm.nih.gov/pubmed/21410464
http://dx.doi.org/10.1111/j.1476-5381.2011.01328.x
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