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Insights from Epidemiology into Dichloromethane and Cancer Risk
Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control studies, including seven of hematopoietic cancers), focusing on specific cancer sites. There was little indication of an increased risk of lun...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166749/ https://www.ncbi.nlm.nih.gov/pubmed/21909313 http://dx.doi.org/10.3390/ijerph8083380 |
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author | Cooper, Glinda S. Scott, Cheryl Siegel Bale, Ambuja S. |
author_facet | Cooper, Glinda S. Scott, Cheryl Siegel Bale, Ambuja S. |
author_sort | Cooper, Glinda S. |
collection | PubMed |
description | Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control studies, including seven of hematopoietic cancers), focusing on specific cancer sites. There was little indication of an increased risk of lung cancer in the cohort studies (standardized mortality ratios ranging from 0.46 to 1.21). These cohorts are relatively small, and variable effects (e.g., point estimates ranging from 0.5 to 2.0) were seen for the rarer forms of cancers such as brain cancer and specific hematopoietic cancers. Three large population-based case-control studies of incident non-Hodgkin lymphoma in Europe and the United States observed odds ratios between 1.5 and 2.2 with dichloromethane exposure (ever exposed or highest category of exposure), with higher risk seen in specific subsets of disease. More limited indications of associations with brain cancer, breast cancer, and liver and biliary cancer were also seen in this collection of studies. Existing cohort studies, given their size and uneven exposure information, are unlikely to resolve questions of cancer risks and dichloromethane exposure. More promising approaches are population-based case-control studies of incident disease, and the combination of data from such studies, with robust exposure assessments that include detailed occupational information and exposure assignment based on industry-wide surveys or direct exposure measurements. |
format | Online Article Text |
id | pubmed-3166749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31667492011-09-09 Insights from Epidemiology into Dichloromethane and Cancer Risk Cooper, Glinda S. Scott, Cheryl Siegel Bale, Ambuja S. Int J Environ Res Public Health Review Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control studies, including seven of hematopoietic cancers), focusing on specific cancer sites. There was little indication of an increased risk of lung cancer in the cohort studies (standardized mortality ratios ranging from 0.46 to 1.21). These cohorts are relatively small, and variable effects (e.g., point estimates ranging from 0.5 to 2.0) were seen for the rarer forms of cancers such as brain cancer and specific hematopoietic cancers. Three large population-based case-control studies of incident non-Hodgkin lymphoma in Europe and the United States observed odds ratios between 1.5 and 2.2 with dichloromethane exposure (ever exposed or highest category of exposure), with higher risk seen in specific subsets of disease. More limited indications of associations with brain cancer, breast cancer, and liver and biliary cancer were also seen in this collection of studies. Existing cohort studies, given their size and uneven exposure information, are unlikely to resolve questions of cancer risks and dichloromethane exposure. More promising approaches are population-based case-control studies of incident disease, and the combination of data from such studies, with robust exposure assessments that include detailed occupational information and exposure assignment based on industry-wide surveys or direct exposure measurements. Molecular Diversity Preservation International (MDPI) 2011-08 2011-08-18 /pmc/articles/PMC3166749/ /pubmed/21909313 http://dx.doi.org/10.3390/ijerph8083380 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Cooper, Glinda S. Scott, Cheryl Siegel Bale, Ambuja S. Insights from Epidemiology into Dichloromethane and Cancer Risk |
title | Insights from Epidemiology into Dichloromethane and Cancer Risk |
title_full | Insights from Epidemiology into Dichloromethane and Cancer Risk |
title_fullStr | Insights from Epidemiology into Dichloromethane and Cancer Risk |
title_full_unstemmed | Insights from Epidemiology into Dichloromethane and Cancer Risk |
title_short | Insights from Epidemiology into Dichloromethane and Cancer Risk |
title_sort | insights from epidemiology into dichloromethane and cancer risk |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166749/ https://www.ncbi.nlm.nih.gov/pubmed/21909313 http://dx.doi.org/10.3390/ijerph8083380 |
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