Permutation criteria to evaluate multiple clinical endpoints in a proof-of-concept study: lessons from Pre-RELAX-AHF

BACKGROUND: Clinically relevant endpoints cannot be routinely targeted with reasonable power in a small study. Hence, proof-of-concept studies are often powered to a primary surrogate endpoint. However, in acute heart failure (AHF) effects on surrogates have not translated into clinical benefit in c...

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Detalles Bibliográficos
Autores principales: Davison, Beth A., Cotter, Gad, Sun, Hengrui, Chen, Li, Teerlink, John R., Metra, Marco, Felker, G. Michael, Voors, Adriaan A., Ponikowski, Piotr, Filippatos, Gerasimos, Greenberg, Barry, Teichman, Sam L., Unemori, Elaine, Koch, Gary G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167045/
https://www.ncbi.nlm.nih.gov/pubmed/21416190
http://dx.doi.org/10.1007/s00392-011-0304-5

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