Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation

It is well documented that PPARα and PPARβ/δ share overlapping functions in regulating myocardial lipid metabolism. However, previous studies demonstrated that cardiomyocyte-restricted PPARβ/δ deficiency in mice leads to severe cardiac pathological development, whereas global PPARα knockout shows a...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Wang, Peiyong, He, Lan, Li, Yuquan, Luo, Jinwen, Cheng, Lihong, Qin, Qianhong, Brako, Lawrence A., Lo, Woo-kuen, Lewis, William, Yang, Qinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167180/
https://www.ncbi.nlm.nih.gov/pubmed/21904539
http://dx.doi.org/10.1155/2011/372854

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