Cargando…

Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria

Lamin A is a component of the nuclear lamina mutated in a group of human inherited disorders known as laminopathies. Among laminopathies, progeroid syndromes and lipodystrophies feature accumulation of prelamin A, the precursor protein which, in normal cells, undergoes a multi-step processing to yie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dominici, S., Fiori, V., Magnani, M., Schena, E., Capanni, C., Camozzi, D., D’Apice, M.R., Le Dour, C., Auclair, M., Caron, M., Novelli, G., Vigouroux, C., Maraldi, N.M., Lattanzi, G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PAGEPress Publications 2009
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167279/ https://www.ncbi.nlm.nih.gov/pubmed/30256865 http://dx.doi.org/10.4081/ejh.2009.e6

Ejemplares similares

Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria
por: Cenni, V., et al.
Publicado: (2011)

Erratum - Autophagic Degradation of Farnesylated Prelamin a as a Therapeutic Approach to Lamin-Linked Progeria
por: Cenni, V., et al.
Publicado: (2013)

Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment
por: Camozzi, Daria, et al.
Publicado: (2012)

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
por: Columbaro, M., et al.
Publicado: (2005)

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
por: Pellegrini, Camilla, et al.
Publicado: (2015)

The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment
por: Capanni, Cristina, et al.
Publicado: (2022)

Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution
por: Capanni, Cristina, et al.
Publicado: (2012)

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
por: de la Rosa, Jorge, et al.
Publicado: (2013)

Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level
por: Bellotti, Chiara, et al.
Publicado: (2016)

Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides
por: Fong, Loren G., et al.
Publicado: (2009)

Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes
por: Loi, Manuela, et al.
Publicado: (2015)

Genomic Instability and DNA Damage Responses in Progeria Arising from Defective Maturation of Prelamin A
por: Musich, Phillip R., et al.
Publicado: (2009)

Rapamycin treatment of Mandibuloacral Dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics
por: Cenni, Vittoria, et al.
Publicado: (2014)

Lamins and bone disorders: current understanding and perspectives
por: Gargiuli, Chiara, et al.
Publicado: (2018)

Status of treatment strategies for Hutchinson–Gilford progeria syndrome with a focus on prelamin: A posttranslational modification
por: Chen, Xue, et al.
Publicado: (2022)

Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model
por: Liu, Baohua, et al.
Publicado: (2013)

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells
por: Evangelisti, Camilla, et al.
Publicado: (2020)

Nuclear damages and oxidative stress: new perspectives for laminopathies
por: Lattanzi, G., et al.
Publicado: (2012)

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies
por: Hartinger, Ramona, et al.
Publicado: (2023)

Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome
por: Donadille, Bruno, et al.
Publicado: (2013)

Nuclear Nox4 interaction with prelamin A is associated with nuclear redox control of stem cell aging
por: Casciaro, Francesca, et al.
Publicado: (2018)

Prelaminated Fascia Lata Free Flap for Oronasal Fistula Reconstruction
por: Cavadas, Pedro C., et al.
Publicado: (2017)

Diverse lamin-dependent mechanisms interact to control chromatin dynamics: Focus on laminopathies
por: Camozzi, Daria, et al.
Publicado: (2014)

Cutaneous and metabolic defects associated with nuclear abnormalities in a transgenic mouse model expressing R527H lamin A mutation causing mandibuloacral dysplasia type A (MADA) syndrome
por: D’Apice, Maria Rosaria, et al.
Publicado: (2020)

Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice
por: Squarzoni, Stefano, et al.
Publicado: (2021)

Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies
por: Brayson, Daniel, et al.
Publicado: (2019)

Prelaminated Temporoparietal Osteofascial Flap: A Novel Nasal Reconstruction Technique
por: Aldana, Celso A., et al.
Publicado: (2021)

Case Report: An Atypical Form of Familial Partial Lipodystrophy Type 2 Due to Mutation in the Rod Domain of Lamin A/C
por: Cecchetti, Carolina, et al.
Publicado: (2021)

Prelaminated Supraclavicular Island Flap for Total Ear Reconstruction: A New Technique
por: Alves, Hélio R. N., et al.
Publicado: (2020)

Progeria
Publicado: (1935)

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria‐related disorders
por: Evangelisti, Camilla, et al.
Publicado: (2016)

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness
por: Levy, Yotam, et al.
Publicado: (2018)

Prelamin A and Oct-1: a puzzle of aging
por: Infante, Arantza, et al.
Publicado: (2015)

Novel mutations of TCOF1 gene in European patients with treacher Collins syndrome
por: Conte, Chiara, et al.
Publicado: (2011)

Living with Progeria
por: Stamsnijder, Marjet
Publicado: (2010)

From Genome-Wide to Environment-Wide: Capturing the Environome
por: von Stumm, Sophie, et al.
Publicado: (2021)

Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24
por: Barrowman, Jemima, et al.
Publicado: (2012)

A novel animal model for skin flap prelamination with biomaterials
por: Zhou, Xianyu, et al.
Publicado: (2016)

Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24
por: Babatz, Timothy D., et al.
Publicado: (2020)

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins
por: Evangelisti, Camilla, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kkhii8nckjcsaeogmefkvetprm