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Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia
Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases are involved in the desensitization of several G protein-coupled receptors (GPCR). However, arrestins can also contribute to GPCR signaling independently from G proteins. In this review, we focus on the role...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167352/ https://www.ncbi.nlm.nih.gov/pubmed/21922001 http://dx.doi.org/10.3389/fnana.2011.00058 |
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author | Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin |
author_facet | Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin |
author_sort | Del’Guidice, Thomas |
collection | PubMed |
description | Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases are involved in the desensitization of several G protein-coupled receptors (GPCR). However, arrestins can also contribute to GPCR signaling independently from G proteins. In this review, we focus on the role of βArr in the regulation of dopamine receptor functions in the striatum. First, we present in vivo evidence supporting a role for these proteins in the regulation of dopamine receptor desensitization. Second, we provide an overview of the roles of βArr2 in the regulation of extracellular-signal-regulated kinases/MAP kinases and Akt/GSK3 signaling pathways downstream of the D1 and D2 dopamine receptors. Thereafter, we examine the possible involvement of βArr-mediated signaling in the action of dopaminergic drugs used for the treatment of mental disorders. Finally, we focus on different potential cellular proteins regulated by βArr-mediated signaling which could contribute to the regulation of behavioral responses to dopamine. Overall, the identification of a cell signaling function for βArr downstream of dopamine receptors underscores the intricate complexity of the intertwined mechanisms regulating and mediating cell signaling in the basal ganglia. Understanding these mechanisms may lead to a better comprehension of the several roles played by these structures in the regulation of mood and to the development of new psychoactive drugs having better therapeutic efficacy. |
format | Online Article Text |
id | pubmed-3167352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31673522011-09-15 Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin Front Neuroanat Neuroscience Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases are involved in the desensitization of several G protein-coupled receptors (GPCR). However, arrestins can also contribute to GPCR signaling independently from G proteins. In this review, we focus on the role of βArr in the regulation of dopamine receptor functions in the striatum. First, we present in vivo evidence supporting a role for these proteins in the regulation of dopamine receptor desensitization. Second, we provide an overview of the roles of βArr2 in the regulation of extracellular-signal-regulated kinases/MAP kinases and Akt/GSK3 signaling pathways downstream of the D1 and D2 dopamine receptors. Thereafter, we examine the possible involvement of βArr-mediated signaling in the action of dopaminergic drugs used for the treatment of mental disorders. Finally, we focus on different potential cellular proteins regulated by βArr-mediated signaling which could contribute to the regulation of behavioral responses to dopamine. Overall, the identification of a cell signaling function for βArr downstream of dopamine receptors underscores the intricate complexity of the intertwined mechanisms regulating and mediating cell signaling in the basal ganglia. Understanding these mechanisms may lead to a better comprehension of the several roles played by these structures in the regulation of mood and to the development of new psychoactive drugs having better therapeutic efficacy. Frontiers Research Foundation 2011-09-06 /pmc/articles/PMC3167352/ /pubmed/21922001 http://dx.doi.org/10.3389/fnana.2011.00058 Text en Copyright © 2011 Del’Guidice, Lemasson and Beaulieu. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Neuroscience Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia |
title | Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia |
title_full | Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia |
title_fullStr | Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia |
title_full_unstemmed | Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia |
title_short | Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia |
title_sort | role of beta-arrestin 2 downstream of dopamine receptors in the basal ganglia |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167352/ https://www.ncbi.nlm.nih.gov/pubmed/21922001 http://dx.doi.org/10.3389/fnana.2011.00058 |
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