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Modified bases enable high-efficiency oligonucleotide-mediated allelic replacement via mismatch repair evasion

Genome engineering using single-stranded oligonucleotides is an efficient method for generating small chromosomal and episomal modifications in a variety of host organisms. The efficiency of this allelic replacement strategy is highly dependent on avoidance of the endogenous mismatch repair (MMR) ma...

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Detalles Bibliográficos
Autores principales:	Wang, Harris H., Xu, George, Vonner, Ashley J., Church, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167615/ https://www.ncbi.nlm.nih.gov/pubmed/21609953 http://dx.doi.org/10.1093/nar/gkr183

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