Human Tumour Immune Evasion via TGF-β Blocks NK Cell Activation but Not Survival Allowing Therapeutic Restoration of Anti-Tumour Activity

Immune evasion is now recognized as a key feature of cancer progression. In animal models, the activity of cytotoxic lymphocytes is suppressed in the tumour microenvironment by the immunosuppressive cytokine, Transforming Growth Factor (TGF)-β. Release from TGF-β-mediated inhibition restores anti-tu...

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Detalles Bibliográficos
Autores principales: Wilson, Erica B., El-Jawhari, Jehan J., Neilson, Abbie L., Hall, Geoffrey D., Melcher, Alan A., Meade, Josephine L., Cook, Graham P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167809/
https://www.ncbi.nlm.nih.gov/pubmed/21909397
http://dx.doi.org/10.1371/journal.pone.0022842

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