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Relationships between Membrane Binding, Affinity and Cell Internalization Efficacy of a Cell-Penetrating Peptide: Penetratin as a Case Study
BACKGROUND: Penetratin is a positively charged cell-penetrating peptide (CPP) that has the ability to bind negatively charged membrane components, such as glycosaminoglycans and anionic lipids. Whether this primary interaction of penetratin with these cell surface components implies that the peptide...
Autores principales: | Alves, Isabel D., Bechara, Cherine, Walrant, Astrid, Zaltsman, Yefim, Jiao, Chen-Yu, Sagan, Sandrine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167814/ https://www.ncbi.nlm.nih.gov/pubmed/21915283 http://dx.doi.org/10.1371/journal.pone.0024096 |
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