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Memory-Based Mismatch Response to Frequency Changes in Rats

Any occasional changes in the acoustic environment are of potential importance for survival. In humans, the preattentive detection of such changes generates the mismatch negativity (MMN) component of event-related brain potentials. MMN is elicited to rare changes (‘deviants’) in a series of otherwis...

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Autores principales: Astikainen, Piia, Stefanics, Gabor, Nokia, Miriam, Lipponen, Arto, Cong, Fengyu, Penttonen, Markku, Ruusuvirta, Timo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167833/
https://www.ncbi.nlm.nih.gov/pubmed/21915297
http://dx.doi.org/10.1371/journal.pone.0024208
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author Astikainen, Piia
Stefanics, Gabor
Nokia, Miriam
Lipponen, Arto
Cong, Fengyu
Penttonen, Markku
Ruusuvirta, Timo
author_facet Astikainen, Piia
Stefanics, Gabor
Nokia, Miriam
Lipponen, Arto
Cong, Fengyu
Penttonen, Markku
Ruusuvirta, Timo
author_sort Astikainen, Piia
collection PubMed
description Any occasional changes in the acoustic environment are of potential importance for survival. In humans, the preattentive detection of such changes generates the mismatch negativity (MMN) component of event-related brain potentials. MMN is elicited to rare changes (‘deviants’) in a series of otherwise regularly repeating stimuli (‘standards’). Deviant stimuli are detected on the basis of a neural comparison process between the input from the current stimulus and the sensory memory trace of the standard stimuli. It is, however, unclear to what extent animals show a similar comparison process in response to auditory changes. To resolve this issue, epidural potentials were recorded above the primary auditory cortex of urethane-anesthetized rats. In an oddball condition, tone frequency was used to differentiate deviants interspersed randomly among a standard tone. Mismatch responses were observed at 60–100 ms after stimulus onset for frequency increases of 5% and 12.5% but not for similarly descending deviants. The response diminished when the silent inter-stimulus interval was increased from 375 ms to 600 ms for +5% deviants and from 600 ms to 1000 ms for +12.5% deviants. In comparison to the oddball condition the response also diminished in a control condition in which no repetitive standards were presented (equiprobable condition). These findings suggest that the rat mismatch response is similar to the human MMN and indicate that anesthetized rats provide a valuable model for studies of central auditory processing.
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spelling pubmed-31678332011-09-13 Memory-Based Mismatch Response to Frequency Changes in Rats Astikainen, Piia Stefanics, Gabor Nokia, Miriam Lipponen, Arto Cong, Fengyu Penttonen, Markku Ruusuvirta, Timo PLoS One Research Article Any occasional changes in the acoustic environment are of potential importance for survival. In humans, the preattentive detection of such changes generates the mismatch negativity (MMN) component of event-related brain potentials. MMN is elicited to rare changes (‘deviants’) in a series of otherwise regularly repeating stimuli (‘standards’). Deviant stimuli are detected on the basis of a neural comparison process between the input from the current stimulus and the sensory memory trace of the standard stimuli. It is, however, unclear to what extent animals show a similar comparison process in response to auditory changes. To resolve this issue, epidural potentials were recorded above the primary auditory cortex of urethane-anesthetized rats. In an oddball condition, tone frequency was used to differentiate deviants interspersed randomly among a standard tone. Mismatch responses were observed at 60–100 ms after stimulus onset for frequency increases of 5% and 12.5% but not for similarly descending deviants. The response diminished when the silent inter-stimulus interval was increased from 375 ms to 600 ms for +5% deviants and from 600 ms to 1000 ms for +12.5% deviants. In comparison to the oddball condition the response also diminished in a control condition in which no repetitive standards were presented (equiprobable condition). These findings suggest that the rat mismatch response is similar to the human MMN and indicate that anesthetized rats provide a valuable model for studies of central auditory processing. Public Library of Science 2011-09-06 /pmc/articles/PMC3167833/ /pubmed/21915297 http://dx.doi.org/10.1371/journal.pone.0024208 Text en Astikainen et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Astikainen, Piia
Stefanics, Gabor
Nokia, Miriam
Lipponen, Arto
Cong, Fengyu
Penttonen, Markku
Ruusuvirta, Timo
Memory-Based Mismatch Response to Frequency Changes in Rats
title Memory-Based Mismatch Response to Frequency Changes in Rats
title_full Memory-Based Mismatch Response to Frequency Changes in Rats
title_fullStr Memory-Based Mismatch Response to Frequency Changes in Rats
title_full_unstemmed Memory-Based Mismatch Response to Frequency Changes in Rats
title_short Memory-Based Mismatch Response to Frequency Changes in Rats
title_sort memory-based mismatch response to frequency changes in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167833/
https://www.ncbi.nlm.nih.gov/pubmed/21915297
http://dx.doi.org/10.1371/journal.pone.0024208
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