Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

Photolysis of aryl azides to give nitrenes, and their subsequent rearrangement in the presence of water to give 3H-azepinones, is performed in continuous flow in a photoreactor constructed of fluorinated ethylene polymer (FEP) tubing. Fine tuning of the reaction conditions using the flow reactor all...

Descripción completa

Detalles Bibliográficos
Autores principales: Bou-Hamdan, Farhan R, Lévesque, François, O'Brien, Alexander G, Seeberger, Peter H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167900/
https://www.ncbi.nlm.nih.gov/pubmed/21915216
http://dx.doi.org/10.3762/bjoc.7.129
Descripción
Sumario:Photolysis of aryl azides to give nitrenes, and their subsequent rearrangement in the presence of water to give 3H-azepinones, is performed in continuous flow in a photoreactor constructed of fluorinated ethylene polymer (FEP) tubing. Fine tuning of the reaction conditions using the flow reactor allowed minimization of secondary photochemical reactions.

Ejemplares similares