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Detection of Extended Spectrum β-lactamase Production Among Uropathogens

BACKGROUND: Detection of extended spectrum β-lactamase (ESBL) production among uropathogens is an important marker of endemicity. AIM: Intervention of this endemic transmission is important for the control of initial outbreak of ESBL producing organisms in a hospital or specialized unit of hospital....

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Detalles Bibliográficos
Autores principales: Aggarwal, Ritu, Chaudhary, Uma, Sikka, Rama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167965/
https://www.ncbi.nlm.nih.gov/pubmed/21938241
http://dx.doi.org/10.4103/0974-2727.44423
Descripción
Sumario:BACKGROUND: Detection of extended spectrum β-lactamase (ESBL) production among uropathogens is an important marker of endemicity. AIM: Intervention of this endemic transmission is important for the control of initial outbreak of ESBL producing organisms in a hospital or specialized unit of hospital. MATERIALS AND METHODS: During the study period of one and a half months, 1,551 urine samples were processed for significant bacteriuria. Two hundred gram negative bacterial isolates were tested for ESBL production. Antimicrobial sensitivity pattern was ascertained for ESBL producing isolates. RESULTS: ESBL production was seen in 36% of isolates. All the isolates were multidrug resistant with uniform sensitivity to imipenem. CONCLUSION: This study reveals the significant prevalence of ESBL producing organisms in this north Indian tertiary care hospital. Constant revision of antibiotic policies with infection control interventions is suggested.