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Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis
Ulcerative colitis (UC) is characterized by a long-standing chronic course with remissions and exacerbations. Previously, patients do not respond to 5-aminosalicylic acid compounds and corticosteroids are considered for colectomies, however, in recent years, alternative treatments emerged for steroi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168385/ https://www.ncbi.nlm.nih.gov/pubmed/21991497 http://dx.doi.org/10.5402/2011/194324 |
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author | Bamba, Shigeki Tsujikawa, Tomoyuki Sasaki, Masaya Fujiyama, Yoshihide Andoh, Akira |
author_facet | Bamba, Shigeki Tsujikawa, Tomoyuki Sasaki, Masaya Fujiyama, Yoshihide Andoh, Akira |
author_sort | Bamba, Shigeki |
collection | PubMed |
description | Ulcerative colitis (UC) is characterized by a long-standing chronic course with remissions and exacerbations. Previously, patients do not respond to 5-aminosalicylic acid compounds and corticosteroids are considered for colectomies, however, in recent years, alternative treatments emerged for steroid-refractory or steroid-dependent UC. In this review article, we focus on immunomodulators (such as azathioprine [AZA] and 6-mercaptopurine [6-MP]) and immunosuppressants (such as cyclosporine A [CSA] and tacrolimus [FK506]) for steroid-refractory or steroid-dependent ulcerative colitis. The characteristics, efficacy and adverse effects of these drugs are outlined. Although the randomized trial of FK506 is conducted in Japan, the clinical data of CSA in Japanese patients are limited. The short-, mid- and long-term follow-ups of CSA administration in Japanese patients are discussed. As for thipurine drugs, the clinical importance of multidrug-resistance protein 4 (MRP4) in Japanese patients is highlighted. |
format | Online Article Text |
id | pubmed-3168385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-31683852011-10-11 Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis Bamba, Shigeki Tsujikawa, Tomoyuki Sasaki, Masaya Fujiyama, Yoshihide Andoh, Akira ISRN Gastroenterol Review Article Ulcerative colitis (UC) is characterized by a long-standing chronic course with remissions and exacerbations. Previously, patients do not respond to 5-aminosalicylic acid compounds and corticosteroids are considered for colectomies, however, in recent years, alternative treatments emerged for steroid-refractory or steroid-dependent UC. In this review article, we focus on immunomodulators (such as azathioprine [AZA] and 6-mercaptopurine [6-MP]) and immunosuppressants (such as cyclosporine A [CSA] and tacrolimus [FK506]) for steroid-refractory or steroid-dependent ulcerative colitis. The characteristics, efficacy and adverse effects of these drugs are outlined. Although the randomized trial of FK506 is conducted in Japan, the clinical data of CSA in Japanese patients are limited. The short-, mid- and long-term follow-ups of CSA administration in Japanese patients are discussed. As for thipurine drugs, the clinical importance of multidrug-resistance protein 4 (MRP4) in Japanese patients is highlighted. International Scholarly Research Network 2011 2011-05-25 /pmc/articles/PMC3168385/ /pubmed/21991497 http://dx.doi.org/10.5402/2011/194324 Text en Copyright © 2011 Shigeki Bamba et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bamba, Shigeki Tsujikawa, Tomoyuki Sasaki, Masaya Fujiyama, Yoshihide Andoh, Akira Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis |
title | Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis |
title_full | Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis |
title_fullStr | Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis |
title_full_unstemmed | Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis |
title_short | Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis |
title_sort | immunomodulators and immunosuppressants for japanese patients with ulcerative colitis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168385/ https://www.ncbi.nlm.nih.gov/pubmed/21991497 http://dx.doi.org/10.5402/2011/194324 |
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