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Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis

Ulcerative colitis (UC) is characterized by a long-standing chronic course with remissions and exacerbations. Previously, patients do not respond to 5-aminosalicylic acid compounds and corticosteroids are considered for colectomies, however, in recent years, alternative treatments emerged for steroi...

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Autores principales: Bamba, Shigeki, Tsujikawa, Tomoyuki, Sasaki, Masaya, Fujiyama, Yoshihide, Andoh, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168385/
https://www.ncbi.nlm.nih.gov/pubmed/21991497
http://dx.doi.org/10.5402/2011/194324
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author Bamba, Shigeki
Tsujikawa, Tomoyuki
Sasaki, Masaya
Fujiyama, Yoshihide
Andoh, Akira
author_facet Bamba, Shigeki
Tsujikawa, Tomoyuki
Sasaki, Masaya
Fujiyama, Yoshihide
Andoh, Akira
author_sort Bamba, Shigeki
collection PubMed
description Ulcerative colitis (UC) is characterized by a long-standing chronic course with remissions and exacerbations. Previously, patients do not respond to 5-aminosalicylic acid compounds and corticosteroids are considered for colectomies, however, in recent years, alternative treatments emerged for steroid-refractory or steroid-dependent UC. In this review article, we focus on immunomodulators (such as azathioprine [AZA] and 6-mercaptopurine [6-MP]) and immunosuppressants (such as cyclosporine A [CSA] and tacrolimus [FK506]) for steroid-refractory or steroid-dependent ulcerative colitis. The characteristics, efficacy and adverse effects of these drugs are outlined. Although the randomized trial of FK506 is conducted in Japan, the clinical data of CSA in Japanese patients are limited. The short-, mid- and long-term follow-ups of CSA administration in Japanese patients are discussed. As for thipurine drugs, the clinical importance of multidrug-resistance protein 4 (MRP4) in Japanese patients is highlighted.
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spelling pubmed-31683852011-10-11 Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis Bamba, Shigeki Tsujikawa, Tomoyuki Sasaki, Masaya Fujiyama, Yoshihide Andoh, Akira ISRN Gastroenterol Review Article Ulcerative colitis (UC) is characterized by a long-standing chronic course with remissions and exacerbations. Previously, patients do not respond to 5-aminosalicylic acid compounds and corticosteroids are considered for colectomies, however, in recent years, alternative treatments emerged for steroid-refractory or steroid-dependent UC. In this review article, we focus on immunomodulators (such as azathioprine [AZA] and 6-mercaptopurine [6-MP]) and immunosuppressants (such as cyclosporine A [CSA] and tacrolimus [FK506]) for steroid-refractory or steroid-dependent ulcerative colitis. The characteristics, efficacy and adverse effects of these drugs are outlined. Although the randomized trial of FK506 is conducted in Japan, the clinical data of CSA in Japanese patients are limited. The short-, mid- and long-term follow-ups of CSA administration in Japanese patients are discussed. As for thipurine drugs, the clinical importance of multidrug-resistance protein 4 (MRP4) in Japanese patients is highlighted. International Scholarly Research Network 2011 2011-05-25 /pmc/articles/PMC3168385/ /pubmed/21991497 http://dx.doi.org/10.5402/2011/194324 Text en Copyright © 2011 Shigeki Bamba et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bamba, Shigeki
Tsujikawa, Tomoyuki
Sasaki, Masaya
Fujiyama, Yoshihide
Andoh, Akira
Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis
title Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis
title_full Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis
title_fullStr Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis
title_full_unstemmed Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis
title_short Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis
title_sort immunomodulators and immunosuppressants for japanese patients with ulcerative colitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168385/
https://www.ncbi.nlm.nih.gov/pubmed/21991497
http://dx.doi.org/10.5402/2011/194324
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