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Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase

BACKGROUND: N348I in HIV-1 reverse transcriptase (RT) confers resistance to zidovudine (AZT) and nevirapine. Biochemical studies demonstrated that N348I indirectly increases AZT resistance by decreasing the frequency of secondary ribonuclease H (RNase H) cleavages that reduce the RNA/DNA duplex leng...

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Detalles Bibliográficos
Autores principales:	Radzio, Jessica, Sluis-Cremer, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168420/ https://www.ncbi.nlm.nih.gov/pubmed/21859446 http://dx.doi.org/10.1186/1742-4690-8-69

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