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Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature
Eosinophilic esophagitis (EE) is increasingly recognized in adults. It is an inflammatory disease of the esophageal mucosa, with variable presentation, unresponsive to acid suppression therapy. The diagnosis requires histological confirmation of intense eosinophilic infiltration on esophageal biopsy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168455/ https://www.ncbi.nlm.nih.gov/pubmed/21991511 http://dx.doi.org/10.5402/2011/468073 |
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author | Shahzad, Ghulamullah Mustacchia, Paul Frieri, Marianne |
author_facet | Shahzad, Ghulamullah Mustacchia, Paul Frieri, Marianne |
author_sort | Shahzad, Ghulamullah |
collection | PubMed |
description | Eosinophilic esophagitis (EE) is increasingly recognized in adults. It is an inflammatory disease of the esophageal mucosa, with variable presentation, unresponsive to acid suppression therapy. The diagnosis requires histological confirmation of intense eosinophilic infiltration on esophageal biopsy specimen, however exact criteria required to make a diagnosis of EE is still being debated and a clear differentiation from gastroesophageal reflux disease (GERD) is important. Allergen elimination or anti-inflammatory therapy may be effective in such patients. The imperfect diagnostic criteria for EE mandate an understanding of the immunology and the pathophysiology of the disease. It may facilitate the introduction of novel treatment modalities in an individual unresponsive to acid suppression therapy. This paper describes basic elements of the immune-mediated injury to the esophageal mucosa and management aspects to provide a better understanding of the condition. |
format | Online Article Text |
id | pubmed-3168455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-31684552011-10-11 Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature Shahzad, Ghulamullah Mustacchia, Paul Frieri, Marianne ISRN Gastroenterol Review Article Eosinophilic esophagitis (EE) is increasingly recognized in adults. It is an inflammatory disease of the esophageal mucosa, with variable presentation, unresponsive to acid suppression therapy. The diagnosis requires histological confirmation of intense eosinophilic infiltration on esophageal biopsy specimen, however exact criteria required to make a diagnosis of EE is still being debated and a clear differentiation from gastroesophageal reflux disease (GERD) is important. Allergen elimination or anti-inflammatory therapy may be effective in such patients. The imperfect diagnostic criteria for EE mandate an understanding of the immunology and the pathophysiology of the disease. It may facilitate the introduction of novel treatment modalities in an individual unresponsive to acid suppression therapy. This paper describes basic elements of the immune-mediated injury to the esophageal mucosa and management aspects to provide a better understanding of the condition. International Scholarly Research Network 2011 2010-11-25 /pmc/articles/PMC3168455/ /pubmed/21991511 http://dx.doi.org/10.5402/2011/468073 Text en Copyright © 2011 Ghulamullah Shahzad et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Shahzad, Ghulamullah Mustacchia, Paul Frieri, Marianne Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature |
title | Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature |
title_full | Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature |
title_fullStr | Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature |
title_full_unstemmed | Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature |
title_short | Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature |
title_sort | role of mucosal inflammation in eosinophilic esophagitis: review of the literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168455/ https://www.ncbi.nlm.nih.gov/pubmed/21991511 http://dx.doi.org/10.5402/2011/468073 |
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