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Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature

Eosinophilic esophagitis (EE) is increasingly recognized in adults. It is an inflammatory disease of the esophageal mucosa, with variable presentation, unresponsive to acid suppression therapy. The diagnosis requires histological confirmation of intense eosinophilic infiltration on esophageal biopsy...

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Autores principales: Shahzad, Ghulamullah, Mustacchia, Paul, Frieri, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168455/
https://www.ncbi.nlm.nih.gov/pubmed/21991511
http://dx.doi.org/10.5402/2011/468073
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author Shahzad, Ghulamullah
Mustacchia, Paul
Frieri, Marianne
author_facet Shahzad, Ghulamullah
Mustacchia, Paul
Frieri, Marianne
author_sort Shahzad, Ghulamullah
collection PubMed
description Eosinophilic esophagitis (EE) is increasingly recognized in adults. It is an inflammatory disease of the esophageal mucosa, with variable presentation, unresponsive to acid suppression therapy. The diagnosis requires histological confirmation of intense eosinophilic infiltration on esophageal biopsy specimen, however exact criteria required to make a diagnosis of EE is still being debated and a clear differentiation from gastroesophageal reflux disease (GERD) is important. Allergen elimination or anti-inflammatory therapy may be effective in such patients. The imperfect diagnostic criteria for EE mandate an understanding of the immunology and the pathophysiology of the disease. It may facilitate the introduction of novel treatment modalities in an individual unresponsive to acid suppression therapy. This paper describes basic elements of the immune-mediated injury to the esophageal mucosa and management aspects to provide a better understanding of the condition.
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spelling pubmed-31684552011-10-11 Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature Shahzad, Ghulamullah Mustacchia, Paul Frieri, Marianne ISRN Gastroenterol Review Article Eosinophilic esophagitis (EE) is increasingly recognized in adults. It is an inflammatory disease of the esophageal mucosa, with variable presentation, unresponsive to acid suppression therapy. The diagnosis requires histological confirmation of intense eosinophilic infiltration on esophageal biopsy specimen, however exact criteria required to make a diagnosis of EE is still being debated and a clear differentiation from gastroesophageal reflux disease (GERD) is important. Allergen elimination or anti-inflammatory therapy may be effective in such patients. The imperfect diagnostic criteria for EE mandate an understanding of the immunology and the pathophysiology of the disease. It may facilitate the introduction of novel treatment modalities in an individual unresponsive to acid suppression therapy. This paper describes basic elements of the immune-mediated injury to the esophageal mucosa and management aspects to provide a better understanding of the condition. International Scholarly Research Network 2011 2010-11-25 /pmc/articles/PMC3168455/ /pubmed/21991511 http://dx.doi.org/10.5402/2011/468073 Text en Copyright © 2011 Ghulamullah Shahzad et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shahzad, Ghulamullah
Mustacchia, Paul
Frieri, Marianne
Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature
title Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature
title_full Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature
title_fullStr Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature
title_full_unstemmed Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature
title_short Role of Mucosal Inflammation in Eosinophilic Esophagitis: Review of the Literature
title_sort role of mucosal inflammation in eosinophilic esophagitis: review of the literature
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168455/
https://www.ncbi.nlm.nih.gov/pubmed/21991511
http://dx.doi.org/10.5402/2011/468073
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