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Tensile Properties of the Murine Ventral Vertical Midline Incision

BACKGROUND: In clinical surgery, the vertical midline abdominal incision is popular but associated with healing failures. A murine model of the ventral vertical midline incision was developed in order to study the healing of this incision type. METHODOLOGY/PRINCIPAL FINDINGS: The strength of the wil...

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Detalles Bibliográficos
Autores principales: Carlson, Mark A., Chakkalakal, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168469/
https://www.ncbi.nlm.nih.gov/pubmed/21915298
http://dx.doi.org/10.1371/journal.pone.0024212
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author Carlson, Mark A.
Chakkalakal, Dennis
author_facet Carlson, Mark A.
Chakkalakal, Dennis
author_sort Carlson, Mark A.
collection PubMed
description BACKGROUND: In clinical surgery, the vertical midline abdominal incision is popular but associated with healing failures. A murine model of the ventral vertical midline incision was developed in order to study the healing of this incision type. METHODOLOGY/PRINCIPAL FINDINGS: The strength of the wild type murine ventral abdominal wall in the midline was contained within the dermis; the linea alba made a negligible contribution. Unwounded abdominal wall had a downward trend (nonsignificant) in maximal tension between 12 and 29 weeks of age. The incision attained 50% of its final strength by postoperative day 40. The maximal tension of the ventral vertical midline incision was nearly that of unwounded abdominal wall by postwounding day 60; there was no difference in unwounded vs. wounded maximal tension at postwounding day 120. CONCLUSIONS/SIGNIFICANCE: After 120 days of healing, the ventral vertical midline incision in the wild type mouse was not significantly different from age-matched nonwounded controls. About half of the final incisional strength was attained after 6 weeks of healing. The significance of this work was to establish the kinetics of wild type incisional healing in a model for which numerous genotypes and genetic tools would be available for subsequent study.
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spelling pubmed-31684692011-09-13 Tensile Properties of the Murine Ventral Vertical Midline Incision Carlson, Mark A. Chakkalakal, Dennis PLoS One Research Article BACKGROUND: In clinical surgery, the vertical midline abdominal incision is popular but associated with healing failures. A murine model of the ventral vertical midline incision was developed in order to study the healing of this incision type. METHODOLOGY/PRINCIPAL FINDINGS: The strength of the wild type murine ventral abdominal wall in the midline was contained within the dermis; the linea alba made a negligible contribution. Unwounded abdominal wall had a downward trend (nonsignificant) in maximal tension between 12 and 29 weeks of age. The incision attained 50% of its final strength by postoperative day 40. The maximal tension of the ventral vertical midline incision was nearly that of unwounded abdominal wall by postwounding day 60; there was no difference in unwounded vs. wounded maximal tension at postwounding day 120. CONCLUSIONS/SIGNIFICANCE: After 120 days of healing, the ventral vertical midline incision in the wild type mouse was not significantly different from age-matched nonwounded controls. About half of the final incisional strength was attained after 6 weeks of healing. The significance of this work was to establish the kinetics of wild type incisional healing in a model for which numerous genotypes and genetic tools would be available for subsequent study. Public Library of Science 2011-09-07 /pmc/articles/PMC3168469/ /pubmed/21915298 http://dx.doi.org/10.1371/journal.pone.0024212 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Carlson, Mark A.
Chakkalakal, Dennis
Tensile Properties of the Murine Ventral Vertical Midline Incision
title Tensile Properties of the Murine Ventral Vertical Midline Incision
title_full Tensile Properties of the Murine Ventral Vertical Midline Incision
title_fullStr Tensile Properties of the Murine Ventral Vertical Midline Incision
title_full_unstemmed Tensile Properties of the Murine Ventral Vertical Midline Incision
title_short Tensile Properties of the Murine Ventral Vertical Midline Incision
title_sort tensile properties of the murine ventral vertical midline incision
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168469/
https://www.ncbi.nlm.nih.gov/pubmed/21915298
http://dx.doi.org/10.1371/journal.pone.0024212
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