Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene

In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was seque...

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Autores principales: Liu, Elizabeth B., Ferreyra, Leonardo, Fischer, Stephen L., Pavan, Jorge V., Nates, Silvia V., Hudson, Nolan Ryan, Tirado, Damaris, Dyer, David W., Chodosh, James, Seto, Donald, Jones, Morris S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168504/
https://www.ncbi.nlm.nih.gov/pubmed/21915339
http://dx.doi.org/10.1371/journal.pone.0024491
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author Liu, Elizabeth B.
Ferreyra, Leonardo
Fischer, Stephen L.
Pavan, Jorge V.
Nates, Silvia V.
Hudson, Nolan Ryan
Tirado, Damaris
Dyer, David W.
Chodosh, James
Seto, Donald
Jones, Morris S.
author_facet Liu, Elizabeth B.
Ferreyra, Leonardo
Fischer, Stephen L.
Pavan, Jorge V.
Nates, Silvia V.
Hudson, Nolan Ryan
Tirado, Damaris
Dyer, David W.
Chodosh, James
Seto, Donald
Jones, Morris S.
author_sort Liu, Elizabeth B.
collection PubMed
description In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event.
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spelling pubmed-31685042011-09-13 Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene Liu, Elizabeth B. Ferreyra, Leonardo Fischer, Stephen L. Pavan, Jorge V. Nates, Silvia V. Hudson, Nolan Ryan Tirado, Damaris Dyer, David W. Chodosh, James Seto, Donald Jones, Morris S. PLoS One Research Article In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event. Public Library of Science 2011-09-07 /pmc/articles/PMC3168504/ /pubmed/21915339 http://dx.doi.org/10.1371/journal.pone.0024491 Text en Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Liu, Elizabeth B.
Ferreyra, Leonardo
Fischer, Stephen L.
Pavan, Jorge V.
Nates, Silvia V.
Hudson, Nolan Ryan
Tirado, Damaris
Dyer, David W.
Chodosh, James
Seto, Donald
Jones, Morris S.
Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene
title Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene
title_full Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene
title_fullStr Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene
title_full_unstemmed Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene
title_short Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene
title_sort genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168504/
https://www.ncbi.nlm.nih.gov/pubmed/21915339
http://dx.doi.org/10.1371/journal.pone.0024491
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