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In vivo and in vitro function of human UDP-galactose 4′-epimerase variants

Type III galactosemia results from reduced activity of the enzyme UDP-galactose 4′-epimerase. Five disease-associated alleles (G90E, V94M, D103G, N34S and L183P) and three artificial alleles (Y105C, N268D, and M284K) were tested for their ability to alleviate galactose-induced growth arrest in a Sac...

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Detalles Bibliográficos
Autores principales:	McCorvie, Thomas J., Wasilenko, Jamie, Liu, Ying, Fridovich-Keil, Judith L., Timson, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editions Scientifiques Elsevier 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168732/ https://www.ncbi.nlm.nih.gov/pubmed/21703329 http://dx.doi.org/10.1016/j.biochi.2011.06.009

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