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Expanding the Genetic Code of an Animal

[Image: see text] Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

Detalles Bibliográficos
Autores principales: Greiss, Sebastian, Chin, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168933/
https://www.ncbi.nlm.nih.gov/pubmed/21819153
http://dx.doi.org/10.1021/ja2054034
Descripción
Sumario:[Image: see text] Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.