One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences

A novel one-pot four-component synthesis of pyrimidyl- and pyrazolylazulenes through the use of glyoxylation–decarbonylative alkynylation–cyclocondensation sequences starting from azulene or guaiazulene as substrates, gives rise to the formation of the target compounds in moderate to good yields....

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Autores principales: Gers, Charlotte F, Rosellen, Julia, Merkul, Eugen, Müller, Thomas J J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168959/
https://www.ncbi.nlm.nih.gov/pubmed/21915223
http://dx.doi.org/10.3762/bjoc.7.136
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author Gers, Charlotte F
Rosellen, Julia
Merkul, Eugen
Müller, Thomas J J
author_facet Gers, Charlotte F
Rosellen, Julia
Merkul, Eugen
Müller, Thomas J J
author_sort Gers, Charlotte F
collection PubMed
description A novel one-pot four-component synthesis of pyrimidyl- and pyrazolylazulenes through the use of glyoxylation–decarbonylative alkynylation–cyclocondensation sequences starting from azulene or guaiazulene as substrates, gives rise to the formation of the target compounds in moderate to good yields.
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spelling pubmed-31689592011-09-13 One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences Gers, Charlotte F Rosellen, Julia Merkul, Eugen Müller, Thomas J J Beilstein J Org Chem Full Research Paper A novel one-pot four-component synthesis of pyrimidyl- and pyrazolylazulenes through the use of glyoxylation–decarbonylative alkynylation–cyclocondensation sequences starting from azulene or guaiazulene as substrates, gives rise to the formation of the target compounds in moderate to good yields. Beilstein-Institut 2011-08-26 /pmc/articles/PMC3168959/ /pubmed/21915223 http://dx.doi.org/10.3762/bjoc.7.136 Text en Copyright © 2011, Gers et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Gers, Charlotte F
Rosellen, Julia
Merkul, Eugen
Müller, Thomas J J
One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
title One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
title_full One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
title_fullStr One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
title_full_unstemmed One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
title_short One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
title_sort one-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168959/
https://www.ncbi.nlm.nih.gov/pubmed/21915223
http://dx.doi.org/10.3762/bjoc.7.136
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