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Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, wit...

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Autores principales: Corrêa, Jôice Dias, Queiroz-Junior, Celso Martins, Costa, José Eustáquio, Teixeira, Antônio Lúcio, Silva, Tarcilia Aparecida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168966/
https://www.ncbi.nlm.nih.gov/pubmed/21991476
http://dx.doi.org/10.5402/2011/497850
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author Corrêa, Jôice Dias
Queiroz-Junior, Celso Martins
Costa, José Eustáquio
Teixeira, Antônio Lúcio
Silva, Tarcilia Aparecida
author_facet Corrêa, Jôice Dias
Queiroz-Junior, Celso Martins
Costa, José Eustáquio
Teixeira, Antônio Lúcio
Silva, Tarcilia Aparecida
author_sort Corrêa, Jôice Dias
collection PubMed
description Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.
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spelling pubmed-31689662011-10-11 Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features Corrêa, Jôice Dias Queiroz-Junior, Celso Martins Costa, José Eustáquio Teixeira, Antônio Lúcio Silva, Tarcilia Aparecida ISRN Dent Review Article Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth. International Scholarly Research Network 2011 2011-07-25 /pmc/articles/PMC3168966/ /pubmed/21991476 http://dx.doi.org/10.5402/2011/497850 Text en Copyright © 2011 Jôice Dias Corrêa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Corrêa, Jôice Dias
Queiroz-Junior, Celso Martins
Costa, José Eustáquio
Teixeira, Antônio Lúcio
Silva, Tarcilia Aparecida
Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features
title Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features
title_full Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features
title_fullStr Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features
title_full_unstemmed Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features
title_short Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features
title_sort phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168966/
https://www.ncbi.nlm.nih.gov/pubmed/21991476
http://dx.doi.org/10.5402/2011/497850
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