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Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features
Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, wit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168966/ https://www.ncbi.nlm.nih.gov/pubmed/21991476 http://dx.doi.org/10.5402/2011/497850 |
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author | Corrêa, Jôice Dias Queiroz-Junior, Celso Martins Costa, José Eustáquio Teixeira, Antônio Lúcio Silva, Tarcilia Aparecida |
author_facet | Corrêa, Jôice Dias Queiroz-Junior, Celso Martins Costa, José Eustáquio Teixeira, Antônio Lúcio Silva, Tarcilia Aparecida |
author_sort | Corrêa, Jôice Dias |
collection | PubMed |
description | Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth. |
format | Online Article Text |
id | pubmed-3168966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-31689662011-10-11 Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features Corrêa, Jôice Dias Queiroz-Junior, Celso Martins Costa, José Eustáquio Teixeira, Antônio Lúcio Silva, Tarcilia Aparecida ISRN Dent Review Article Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth. International Scholarly Research Network 2011 2011-07-25 /pmc/articles/PMC3168966/ /pubmed/21991476 http://dx.doi.org/10.5402/2011/497850 Text en Copyright © 2011 Jôice Dias Corrêa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Corrêa, Jôice Dias Queiroz-Junior, Celso Martins Costa, José Eustáquio Teixeira, Antônio Lúcio Silva, Tarcilia Aparecida Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features |
title | Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features |
title_full | Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features |
title_fullStr | Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features |
title_full_unstemmed | Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features |
title_short | Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features |
title_sort | phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168966/ https://www.ncbi.nlm.nih.gov/pubmed/21991476 http://dx.doi.org/10.5402/2011/497850 |
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