An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-β Mediates Gα(q) Activation

Phospholipase C-β (PLCβ) is a key regulator of intracellular calcium levels whose activity is controlled by heptahelical receptors that couple to G(q). We have determined atomic structures of two invertebrate homologs of PLCβ (PLC21) from cephalopod retina and identified a helix from the C-terminal...

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Detalles Bibliográficos
Autores principales: Lyon, Angeline M., Tesmer, Valerie M., Dhamsania, Vishan D., Thal, David M., Gutierrez, Joanne, Chowdhury, Shoaib, Suddala, Krishna C., Northup, John K., Tesmer, John J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168981/
https://www.ncbi.nlm.nih.gov/pubmed/21822282
http://dx.doi.org/10.1038/nsmb.2095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168981/
https://www.ncbi.nlm.nih.gov/pubmed/21822282
http://dx.doi.org/10.1038/nsmb.2095

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