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H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing

BACKGROUND: Endogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-deposited trimethylated lysine 9 of histone 3 (H3K9me3), but the mechanism of H3K9m...

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Detalles Bibliográficos
Autores principales:	Maksakova, Irina A, Goyal, Preeti, Bullwinkel, Jörn, Brown, Jeremy P, Bilenky, Misha, Mager, Dixie L, Singh, Prim B, Lorincz, Matthew C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169442/ https://www.ncbi.nlm.nih.gov/pubmed/21774827 http://dx.doi.org/10.1186/1756-8935-4-12

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