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Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico

BACKGROUND: Human exposures to inorganic arsenic (iAs) have been linked to an increased risk of diabetes mellitus. Recent laboratory studies showed that methylated trivalent metabolites of iAs may play key roles in the diabetogenic effects of iAs. Our study examined associations between chronic expo...

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Autores principales: Del Razo, Luz M, García-Vargas, Gonzalo G, Valenzuela, Olga L, Castellanos, Erika Hernández, Sánchez-Peña, Luz C, Currier, Jenna M, Drobná, Zuzana, Loomis, Dana, Stýblo, Miroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169452/
https://www.ncbi.nlm.nih.gov/pubmed/21864395
http://dx.doi.org/10.1186/1476-069X-10-73
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author Del Razo, Luz M
García-Vargas, Gonzalo G
Valenzuela, Olga L
Castellanos, Erika Hernández
Sánchez-Peña, Luz C
Currier, Jenna M
Drobná, Zuzana
Loomis, Dana
Stýblo, Miroslav
author_facet Del Razo, Luz M
García-Vargas, Gonzalo G
Valenzuela, Olga L
Castellanos, Erika Hernández
Sánchez-Peña, Luz C
Currier, Jenna M
Drobná, Zuzana
Loomis, Dana
Stýblo, Miroslav
author_sort Del Razo, Luz M
collection PubMed
description BACKGROUND: Human exposures to inorganic arsenic (iAs) have been linked to an increased risk of diabetes mellitus. Recent laboratory studies showed that methylated trivalent metabolites of iAs may play key roles in the diabetogenic effects of iAs. Our study examined associations between chronic exposure to iAs in drinking water, metabolism of iAs, and prevalence of diabetes in arsenicosis-endemic areas of Mexico. METHODS: We used fasting blood glucose (FBG), fasting plasma insulin (FPI), oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), and insulin resistance (HOMA-IR) to characterize diabetic individuals. Arsenic levels in drinking water and urine were determined to estimate exposure to iAs. Urinary concentrations of iAs and its trivalent and pentavalent methylated metabolites were measured to assess iAs metabolism. Associations between diabetes and iAs exposure or urinary metabolites of iAs were estimated by logistic regression with adjustment for age, sex, hypertension and obesity. RESULTS: The prevalence of diabetes was positively associated with iAs in drinking water (OR 1.13 per 10 ppb, p < 0.01) and with the concentration of dimethylarsinite (DMAs(III)) in urine (OR 1.24 per inter-quartile range, p = 0.05). Notably, FPI and HOMA-IR were negatively associated with iAs exposure (β -2.08 and -1.64, respectively, p < 0.01), suggesting that the mechanisms of iAs-induced diabetes differ from those underlying type-2 diabetes, which is typically characterized by insulin resistance. CONCLUSIONS: Our study confirms a previously reported, but frequently questioned, association between exposure to iAs and diabetes, and is the first to link the risk of diabetes to the production of one of the most toxic metabolites of iAs, DMAs(III).
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spelling pubmed-31694522011-09-09 Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico Del Razo, Luz M García-Vargas, Gonzalo G Valenzuela, Olga L Castellanos, Erika Hernández Sánchez-Peña, Luz C Currier, Jenna M Drobná, Zuzana Loomis, Dana Stýblo, Miroslav Environ Health Research BACKGROUND: Human exposures to inorganic arsenic (iAs) have been linked to an increased risk of diabetes mellitus. Recent laboratory studies showed that methylated trivalent metabolites of iAs may play key roles in the diabetogenic effects of iAs. Our study examined associations between chronic exposure to iAs in drinking water, metabolism of iAs, and prevalence of diabetes in arsenicosis-endemic areas of Mexico. METHODS: We used fasting blood glucose (FBG), fasting plasma insulin (FPI), oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), and insulin resistance (HOMA-IR) to characterize diabetic individuals. Arsenic levels in drinking water and urine were determined to estimate exposure to iAs. Urinary concentrations of iAs and its trivalent and pentavalent methylated metabolites were measured to assess iAs metabolism. Associations between diabetes and iAs exposure or urinary metabolites of iAs were estimated by logistic regression with adjustment for age, sex, hypertension and obesity. RESULTS: The prevalence of diabetes was positively associated with iAs in drinking water (OR 1.13 per 10 ppb, p < 0.01) and with the concentration of dimethylarsinite (DMAs(III)) in urine (OR 1.24 per inter-quartile range, p = 0.05). Notably, FPI and HOMA-IR were negatively associated with iAs exposure (β -2.08 and -1.64, respectively, p < 0.01), suggesting that the mechanisms of iAs-induced diabetes differ from those underlying type-2 diabetes, which is typically characterized by insulin resistance. CONCLUSIONS: Our study confirms a previously reported, but frequently questioned, association between exposure to iAs and diabetes, and is the first to link the risk of diabetes to the production of one of the most toxic metabolites of iAs, DMAs(III). BioMed Central 2011-08-24 /pmc/articles/PMC3169452/ /pubmed/21864395 http://dx.doi.org/10.1186/1476-069X-10-73 Text en Copyright ©2011 Del Razo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Del Razo, Luz M
García-Vargas, Gonzalo G
Valenzuela, Olga L
Castellanos, Erika Hernández
Sánchez-Peña, Luz C
Currier, Jenna M
Drobná, Zuzana
Loomis, Dana
Stýblo, Miroslav
Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
title Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
title_full Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
title_fullStr Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
title_full_unstemmed Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
title_short Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
title_sort exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the zimapán and lagunera regions in mexico
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169452/
https://www.ncbi.nlm.nih.gov/pubmed/21864395
http://dx.doi.org/10.1186/1476-069X-10-73
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