Cargando…

A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania

BACKGROUND: Effective mass drug administration (MDA) with anti-malarial drugs can clear the human infectious reservoir for malaria and thereby interrupt malaria transmission. The likelihood of success of MDA depends on the intensity and seasonality of malaria transmission, the efficacy of the interv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shekalaghe, Seif A, Drakeley, Chris, van den Bosch, Sven, ter Braak, Roel, van den Bijllaardt, Wouter, Mwanziva, Charles, Semvua, Salimu, Masokoto, Alutu, Mosha, Frank, Teelen, Karina, Hermsen, Rob, Okell, Lucy, Gosling, Roly, Sauerwein, Robert, Bousema, Teun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169516/ https://www.ncbi.nlm.nih.gov/pubmed/21864343 http://dx.doi.org/10.1186/1475-2875-10-247

Ejemplares similares

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
por: Bousema, Teun, et al.
Publicado: (2010)

Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria
por: Mwanziva, Charles, et al.
Publicado: (2008)

Primaquine Clears Submicroscopic Plasmodium falciparum Gametocytes that Persist after Treatment with Sulphadoxine-Pyrimethamine and Artesunate
por: Shekalaghe, Seif, et al.
Publicado: (2007)

Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
por: White, Nicholas J, et al.
Publicado: (2014)

Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity
por: Chotsiri, Palang, et al.
Publicado: (2022)

Low density parasitaemia, red blood cell polymorphisms and Plasmodium falciparum specific immune responses in a low endemic area in northern Tanzania
por: Shekalaghe, Seif, et al.
Publicado: (2009)

CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum
por: Pett, Helmi, et al.
Publicado: (2019)

Rapid Assessment of Malaria Transmission Using Age-Specific Sero-Conversion Rates
por: Stewart, Laveta, et al.
Publicado: (2009)

Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether–lumefantrine
por: Shekalaghe, Seif, et al.
Publicado: (2020)

Finding hotspots: the role of active surveillance methods in malaria control and elimination
por: Sturrock, Hugh JW, et al.
Publicado: (2012)

Chemical signatures and new drug targets for gametocytocidal drug development
por: Sun, Wei, et al.
Publicado: (2014)

Hitting Hotspots: Spatial Targeting of Malaria for Control and Elimination
por: Bousema, Teun, et al.
Publicado: (2012)

Filter paper collection of Plasmodium falciparum mRNA for detecting low-density gametocytes
por: Jones, Sophie, et al.
Publicado: (2012)

The gametocytocidal efficacy of primaquine in malaria asymptomatic carriers treated with dihydroartemisinin-piperaquine in The Gambia (PRINOGAM): study protocol for a randomised controlled trial
por: Okebe, Joseph, et al.
Publicado: (2015)

The Gametocytocidal Efficacy of Different Single Doses of Primaquine with Dihydroartemisinin-piperaquine in Asymptomatic Parasite Carriers in The Gambia: A Randomized Controlled Trial()
por: Okebe, Joseph, et al.
Publicado: (2016)

Rationale for short course primaquine in Africa to interrupt malaria transmission
por: Eziefula, Alice C, et al.
Publicado: (2012)

An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa
por: Chen, Ingrid, et al.
Publicado: (2015)

Spatial and temporal variation in malaria transmission in a low endemicity area in northern Tanzania
por: Oesterholt, MJAM, et al.
Publicado: (2006)

Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics
por: Mosha, Jacklin F, et al.
Publicado: (2013)

Residual Plasmodium falciparum Parasitemia in Kenyan Children After Artemisinin-Combination Therapy Is Associated With Increased Transmission to Mosquitoes and Parasite Recurrence
por: Beshir, Khalid B., et al.
Publicado: (2013)

Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy
por: Birkholtz, Lyn-Marie, et al.
Publicado: (2014)

Extended malaria parasite clearance time in African children following artemisinin-combination therapy enhances transmission to Anopheles mosquitoes
por: Beshir, Khalid B, et al.
Publicado: (2012)

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data
por: Stepniewska, Kasia, et al.
Publicado: (2022)

Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials
por: Kiszewski, Anthony E.
Publicado: (2010)

Malaria diagnostic testing and treatment practices in three different Plasmodium falciparum transmission settings in Tanzania: before and after a government policy change
por: Bastiaens, Guido JH, et al.
Publicado: (2011)

Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio
por: Bradley, John, et al.
Publicado: (2019)

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials
por: Okell, Lucy C, et al.
Publicado: (2008)

In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine
por: Forkuo, Arnold Donkor, et al.
Publicado: (2017)

Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity
por: Okell, Lucy C, et al.
Publicado: (2008)

The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania
por: Bousema, Teun, et al.
Publicado: (2010)

IgG Responses to Anopheles gambiae Salivary Antigen gSG6 Detect Variation in Exposure to Malaria Vectors and Disease Risk
por: Stone, Will, et al.
Publicado: (2012)

Malaria Diagnosis and Treatment: One Size Does Not Fit All
por: Drakeley, Chris, et al.
Publicado: (2005)

Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum
por: Reader, Janette, et al.
Publicado: (2022)

Factors determining the occurrence of submicroscopic malaria infections and their relevance for control
por: Okell, Lucy C., et al.
Publicado: (2012)

Global patterns of submicroscopic Plasmodium falciparum malaria infection: insights from a systematic review and meta-analysis of population surveys
por: Whittaker, Charles, et al.
Publicado: (2021)

Is Housing Quality Associated with Malaria Incidence among Young Children and Mosquito Vector Numbers? Evidence from Korogwe, Tanzania
por: Liu, Jenny X., et al.
Publicado: (2014)

The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia
por: Tadesse, Fitsum G., et al.
Publicado: (2017)

CYP2D6 intermediate metabolizer status could slow down Plasmodium falciparum gametocyte clearance after single-dose primaquine
por: Pett, Helmi, et al.
Publicado: (2014)

Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians
por: Mahamar, Almahamoudou, et al.
Publicado: (2021)

Targeting Asymptomatic Malaria Infections: Active Surveillance in Control and Elimination
por: Sturrock, Hugh J. W., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_19ikdtuhihrvl2aklucuhlvsof