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A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery

Circadian timing largely modifies efficacy and toxicity of many anticancer drugs. Recent findings suggest that optimal circadian delivery patterns depend on the patient genetic background. We present here a combined experimental and mathematical approach for the design of chronomodulated administrat...

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Detalles Bibliográficos
Autores principales:	Ballesta, Annabelle, Dulong, Sandrine, Abbara, Chadi, Cohen, Boris, Okyar, Alper, Clairambault, Jean, Levi, Francis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169519/ https://www.ncbi.nlm.nih.gov/pubmed/21931543 http://dx.doi.org/10.1371/journal.pcbi.1002143

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