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Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/proteasome system (UPS). Previous studies have described an age-de...

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Detalles Bibliográficos
Autores principales:	Kruegel, Undine, Robison, Brett, Dange, Thomas, Kahlert, Günther, Delaney, Joe R., Kotireddy, Soumya, Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Murakami, Christopher J., Schleit, Jennifer, Sutphin, George, Carr, Daniel, Tar, Krisztina, Dittmar, Gunnar, Kaeberlein, Matt, Kennedy, Brian K., Schmidt, Marion
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169524/ https://www.ncbi.nlm.nih.gov/pubmed/21931558 http://dx.doi.org/10.1371/journal.pgen.1002253

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