PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis. In Saccharomyces cerevisiae a key event in TLS is the monoubiquitination of PCNA, which enables re...

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Detalles Bibliográficos
Autores principales: Hendel, Ayal, Krijger, Peter H. L., Diamant, Noam, Goren, Zohar, Langerak, Petra, Kim, Jungmin, Reißner, Thomas, Lee, Kyoo-young, Geacintov, Nicholas E., Carell, Thomas, Myung, Kyungjae, Tateishi, Satoshi, D'Andrea, Alan, Jacobs, Heinz, Livneh, Zvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169526/
https://www.ncbi.nlm.nih.gov/pubmed/21931560
http://dx.doi.org/10.1371/journal.pgen.1002262

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