A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of indi...

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Detalles Bibliográficos
Autores principales: Nicholson, George, Rantalainen, Mattias, Li, Jia V., Maher, Anthony D., Malmodin, Daniel, Ahmadi, Kourosh R., Faber, Johan H., Barrett, Amy, Min, Josine L., Rayner, N. William, Toft, Henrik, Krestyaninova, Maria, Viksna, Juris, Neogi, Sudeshna Guha, Dumas, Marc-Emmanuel, Sarkans, Ugis, Donnelly, Peter, Illig, Thomas, Adamski, Jerzy, Suhre, Karsten, Allen, Maxine, Zondervan, Krina T., Spector, Tim D., Nicholson, Jeremy K., Lindon, John C., Baunsgaard, Dorrit, Holmes, Elaine, McCarthy, Mark I., Holmes, Chris C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169529/
https://www.ncbi.nlm.nih.gov/pubmed/21931564
http://dx.doi.org/10.1371/journal.pgen.1002270

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