Specific Interaction of Gαi3 with the Oa1 G-Protein Coupled Receptor Controls the Size and Density of Melanosomes in Retinal Pigment Epithelium

BACKGROUND: Ocular albinism type 1, an X-linked disease characterized by the presence of enlarged melanosomes in the retinal pigment epithelium (RPE) and abnormal crossing of axons at the optic chiasm, is caused by mutations in the OA1 gene. The protein product of this gene is a G-protein-coupled re...

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Detalles Bibliográficos
Autores principales: Young, Alejandra, Jiang, Meisheng, Wang, Ying, Ahmedli, Novruz B., Ramirez, John, Reese, Benjamin E., Birnbaumer, Lutz, Farber, Debora B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169599/
https://www.ncbi.nlm.nih.gov/pubmed/21931697
http://dx.doi.org/10.1371/journal.pone.0024376

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