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Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis

BACKGROUND: The endogenous cannabinoid system is involved in the control of pain. However, little is known as to the integrity of the cannabinoid system in human pain syndromes. Here we investigate the expression of the cannabinoid receptor 1 (CB(1)) in human Achilles tendons from healthy volunteers...

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Autores principales: Björklund, Emmelie, Forsgren, Sture, Alfredson, Håkan, Fowler, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169627/
https://www.ncbi.nlm.nih.gov/pubmed/21931835
http://dx.doi.org/10.1371/journal.pone.0024731
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author Björklund, Emmelie
Forsgren, Sture
Alfredson, Håkan
Fowler, Christopher J.
author_facet Björklund, Emmelie
Forsgren, Sture
Alfredson, Håkan
Fowler, Christopher J.
author_sort Björklund, Emmelie
collection PubMed
description BACKGROUND: The endogenous cannabinoid system is involved in the control of pain. However, little is known as to the integrity of the cannabinoid system in human pain syndromes. Here we investigate the expression of the cannabinoid receptor 1 (CB(1)) in human Achilles tendons from healthy volunteers and from patients with Achilles tendinosis. METHODOLOGY: Cannabinoid CB(1) receptor immunoreactivity (CB(1)IR) was evaluated in formalin-fixed biopsies from individuals suffering from painful Achilles tendinosis in comparison with healthy human Achilles tendons. PRINCIPAL FINDINGS: CB(1)IR was seen as a granular pattern in the tenocytes. CB(1)IR was also observed in the blood vessel wall and in the perineurium of the nerve. Quantification of the immunoreactivity in tenocytes showed an increase of CB(1) receptor expression in tendinosis tissue compared to control tissue. CONCLUSION: Expression of cannabinoid receptor 1 is increased in human Achilles tendinosis suggesting that the cannabinoid system may be dysregulated in this disorder.
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spelling pubmed-31696272011-09-19 Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis Björklund, Emmelie Forsgren, Sture Alfredson, Håkan Fowler, Christopher J. PLoS One Research Article BACKGROUND: The endogenous cannabinoid system is involved in the control of pain. However, little is known as to the integrity of the cannabinoid system in human pain syndromes. Here we investigate the expression of the cannabinoid receptor 1 (CB(1)) in human Achilles tendons from healthy volunteers and from patients with Achilles tendinosis. METHODOLOGY: Cannabinoid CB(1) receptor immunoreactivity (CB(1)IR) was evaluated in formalin-fixed biopsies from individuals suffering from painful Achilles tendinosis in comparison with healthy human Achilles tendons. PRINCIPAL FINDINGS: CB(1)IR was seen as a granular pattern in the tenocytes. CB(1)IR was also observed in the blood vessel wall and in the perineurium of the nerve. Quantification of the immunoreactivity in tenocytes showed an increase of CB(1) receptor expression in tendinosis tissue compared to control tissue. CONCLUSION: Expression of cannabinoid receptor 1 is increased in human Achilles tendinosis suggesting that the cannabinoid system may be dysregulated in this disorder. Public Library of Science 2011-09-08 /pmc/articles/PMC3169627/ /pubmed/21931835 http://dx.doi.org/10.1371/journal.pone.0024731 Text en Björklund et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Björklund, Emmelie
Forsgren, Sture
Alfredson, Håkan
Fowler, Christopher J.
Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis
title Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis
title_full Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis
title_fullStr Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis
title_full_unstemmed Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis
title_short Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis
title_sort increased expression of cannabinoid cb(1) receptors in achilles tendinosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169627/
https://www.ncbi.nlm.nih.gov/pubmed/21931835
http://dx.doi.org/10.1371/journal.pone.0024731
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