N-Glycans and Glycosylphosphatidylinositol-Anchor Act on Polarized Sorting of Mouse PrP(C) in Madin-Darby Canine Kidney Cells

The cellular prion protein (PrP(C)) plays a fundamental role in prion disease. PrP(C) is a glycosylphosphatidylinositol (GPI)-anchored protein with two variably occupied N-glycosylation sites. In general, GPI-anchor and N-glycosylation direct proteins to apical membranes in polarized cells whereas t...

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Detalles Bibliográficos
Autores principales: Puig, Berta, Altmeppen, Hermann C., Thurm, Dana, Geissen, Markus, Conrad, Catharina, Braulke, Thomas, Glatzel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169634/
https://www.ncbi.nlm.nih.gov/pubmed/21931781
http://dx.doi.org/10.1371/journal.pone.0024624

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