An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome

Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, and isosexual precocious puberty. A 10.7-year-old girl presented with premature menarche and isosexual precocity. She had delayed bone age and multicystic ovaries. High circulating levels of TSH with prep...

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Detalles Bibliográficos
Autores principales: Rastogi, Ashu, Bhadada, Sanjay Kumar, Bhansali, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169870/
https://www.ncbi.nlm.nih.gov/pubmed/21966653
http://dx.doi.org/10.4103/2230-8210.83356
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author Rastogi, Ashu
Bhadada, Sanjay Kumar
Bhansali, Anil
author_facet Rastogi, Ashu
Bhadada, Sanjay Kumar
Bhansali, Anil
author_sort Rastogi, Ashu
collection PubMed
description Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, and isosexual precocious puberty. A 10.7-year-old girl presented with premature menarche and isosexual precocity. She had delayed bone age and multicystic ovaries. High circulating levels of TSH with prepubertal LH confirmed the diagnosis of VWGS. Tendency to manifest sexual precocity in VWGS may be directly related to the severity of the TSH elevation. High circulating levels of TSH acting directly on FSH receptors are the actual mediators of precocity.
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spelling pubmed-31698702011-09-30 An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome Rastogi, Ashu Bhadada, Sanjay Kumar Bhansali, Anil Indian J Endocrinol Metab Case Report Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, and isosexual precocious puberty. A 10.7-year-old girl presented with premature menarche and isosexual precocity. She had delayed bone age and multicystic ovaries. High circulating levels of TSH with prepubertal LH confirmed the diagnosis of VWGS. Tendency to manifest sexual precocity in VWGS may be directly related to the severity of the TSH elevation. High circulating levels of TSH acting directly on FSH receptors are the actual mediators of precocity. Medknow Publications 2011-07 /pmc/articles/PMC3169870/ /pubmed/21966653 http://dx.doi.org/10.4103/2230-8210.83356 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rastogi, Ashu
Bhadada, Sanjay Kumar
Bhansali, Anil
An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome
title An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome
title_full An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome
title_fullStr An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome
title_full_unstemmed An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome
title_short An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome
title_sort unusual presentation of a usual disorder: van wyk-grumbach syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169870/
https://www.ncbi.nlm.nih.gov/pubmed/21966653
http://dx.doi.org/10.4103/2230-8210.83356
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