Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms

Research aimed at understanding amyotrophic lateral sclerosis (ALS) has seen exceptional growth in the past few years. New genes, new models, and new mechanisms have not only improved our understanding, but also contributed to the increasing complexity of ALS pathogenesis. The focus of this piece is...

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Detalles Bibliográficos
Autores principales: Vande Velde, Christine, Dion, Patrick A., Rouleau, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169903/
https://www.ncbi.nlm.nih.gov/pubmed/21941597
http://dx.doi.org/10.3410/B3-18
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author Vande Velde, Christine
Dion, Patrick A.
Rouleau, Guy A.
author_facet Vande Velde, Christine
Dion, Patrick A.
Rouleau, Guy A.
author_sort Vande Velde, Christine
collection PubMed
description Research aimed at understanding amyotrophic lateral sclerosis (ALS) has seen exceptional growth in the past few years. New genes, new models, and new mechanisms have not only improved our understanding, but also contributed to the increasing complexity of ALS pathogenesis. The focus of this piece is to highlight some of the more notable developments in the field and to encourage a re-appreciation for the superoxide dismutase 1 (SOD1) mouse models.
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spelling pubmed-31699032011-09-22 Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms Vande Velde, Christine Dion, Patrick A. Rouleau, Guy A. F1000 Biol Rep Review Article Research aimed at understanding amyotrophic lateral sclerosis (ALS) has seen exceptional growth in the past few years. New genes, new models, and new mechanisms have not only improved our understanding, but also contributed to the increasing complexity of ALS pathogenesis. The focus of this piece is to highlight some of the more notable developments in the field and to encourage a re-appreciation for the superoxide dismutase 1 (SOD1) mouse models. Faculty of 1000 Ltd 2011-09-01 /pmc/articles/PMC3169903/ /pubmed/21941597 http://dx.doi.org/10.3410/B3-18 Text en © 2011 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Vande Velde, Christine
Dion, Patrick A.
Rouleau, Guy A.
Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms
title Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms
title_full Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms
title_fullStr Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms
title_full_unstemmed Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms
title_short Amyotrophic lateral sclerosis: new genes, new models, and new mechanisms
title_sort amyotrophic lateral sclerosis: new genes, new models, and new mechanisms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169903/
https://www.ncbi.nlm.nih.gov/pubmed/21941597
http://dx.doi.org/10.3410/B3-18
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