Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease ac...

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Autores principales: Gulevich, Anton V, Koroleva, Lyudmila S, Morozova, Olga V, Bakhvalova, Valentina N, Silnikov, Vladimir N, Nenajdenko, Valentine G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170195/
https://www.ncbi.nlm.nih.gov/pubmed/21915218
http://dx.doi.org/10.3762/bjoc.7.131
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author Gulevich, Anton V
Koroleva, Lyudmila S
Morozova, Olga V
Bakhvalova, Valentina N
Silnikov, Vladimir N
Nenajdenko, Valentine G
author_facet Gulevich, Anton V
Koroleva, Lyudmila S
Morozova, Olga V
Bakhvalova, Valentina N
Silnikov, Vladimir N
Nenajdenko, Valentine G
author_sort Gulevich, Anton V
collection PubMed
description The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.
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spelling pubmed-31701952011-09-13 Multicomponent synthesis of artificial nucleases and their RNase and DNase activity Gulevich, Anton V Koroleva, Lyudmila S Morozova, Olga V Bakhvalova, Valentina N Silnikov, Vladimir N Nenajdenko, Valentine G Beilstein J Org Chem Full Research Paper The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA. Beilstein-Institut 2011-08-19 /pmc/articles/PMC3170195/ /pubmed/21915218 http://dx.doi.org/10.3762/bjoc.7.131 Text en Copyright © 2011, Gulevich et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Gulevich, Anton V
Koroleva, Lyudmila S
Morozova, Olga V
Bakhvalova, Valentina N
Silnikov, Vladimir N
Nenajdenko, Valentine G
Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
title Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
title_full Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
title_fullStr Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
title_full_unstemmed Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
title_short Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
title_sort multicomponent synthesis of artificial nucleases and their rnase and dnase activity
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170195/
https://www.ncbi.nlm.nih.gov/pubmed/21915218
http://dx.doi.org/10.3762/bjoc.7.131
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