Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts

The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording hi...

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Autores principales: Vicente-García, Esther, Ramón, Rosario, Preciado, Sara, Lavilla, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170197/
https://www.ncbi.nlm.nih.gov/pubmed/21915197
http://dx.doi.org/10.3762/bjoc.7.110
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author Vicente-García, Esther
Ramón, Rosario
Preciado, Sara
Lavilla, Rodolfo
author_facet Vicente-García, Esther
Ramón, Rosario
Preciado, Sara
Lavilla, Rodolfo
author_sort Vicente-García, Esther
collection PubMed
description The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording higher yields, cleaner reactions and practical protocols.
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spelling pubmed-31701972011-09-13 Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts Vicente-García, Esther Ramón, Rosario Preciado, Sara Lavilla, Rodolfo Beilstein J Org Chem Full Research Paper The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording higher yields, cleaner reactions and practical protocols. Beilstein-Institut 2011-07-13 /pmc/articles/PMC3170197/ /pubmed/21915197 http://dx.doi.org/10.3762/bjoc.7.110 Text en Copyright © 2011, Vicente-García et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Vicente-García, Esther
Ramón, Rosario
Preciado, Sara
Lavilla, Rodolfo
Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
title Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
title_full Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
title_fullStr Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
title_full_unstemmed Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
title_short Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
title_sort multicomponent reaction access to complex quinolines via oxidation of the povarov adducts
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170197/
https://www.ncbi.nlm.nih.gov/pubmed/21915197
http://dx.doi.org/10.3762/bjoc.7.110
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