Reductive amination with zinc powder in aqueous media

Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydr...

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Detalles Bibliográficos
Autores principales: Giovenzana, Giovanni B, Imperio, Daniela, Penoni, Andrea, Palmisano, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170205/
https://www.ncbi.nlm.nih.gov/pubmed/21915212
http://dx.doi.org/10.3762/bjoc.7.125
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author Giovenzana, Giovanni B
Imperio, Daniela
Penoni, Andrea
Palmisano, Giovanni
author_facet Giovenzana, Giovanni B
Imperio, Daniela
Penoni, Andrea
Palmisano, Giovanni
author_sort Giovenzana, Giovanni B
collection PubMed
description Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.
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spelling pubmed-31702052011-09-13 Reductive amination with zinc powder in aqueous media Giovenzana, Giovanni B Imperio, Daniela Penoni, Andrea Palmisano, Giovanni Beilstein J Org Chem Letter Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents. Beilstein-Institut 2011-08-10 /pmc/articles/PMC3170205/ /pubmed/21915212 http://dx.doi.org/10.3762/bjoc.7.125 Text en Copyright © 2011, Giovenzana et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Giovenzana, Giovanni B
Imperio, Daniela
Penoni, Andrea
Palmisano, Giovanni
Reductive amination with zinc powder in aqueous media
title Reductive amination with zinc powder in aqueous media
title_full Reductive amination with zinc powder in aqueous media
title_fullStr Reductive amination with zinc powder in aqueous media
title_full_unstemmed Reductive amination with zinc powder in aqueous media
title_short Reductive amination with zinc powder in aqueous media
title_sort reductive amination with zinc powder in aqueous media
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170205/
https://www.ncbi.nlm.nih.gov/pubmed/21915212
http://dx.doi.org/10.3762/bjoc.7.125
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