Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling

The use of FeCl(3) resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO(2...

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Autores principales: Nagaki, Aiichiro, Uesugi, Yuki, Tomida, Yutaka, Yoshida, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170206/
https://www.ncbi.nlm.nih.gov/pubmed/21915209
http://dx.doi.org/10.3762/bjoc.7.122
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author Nagaki, Aiichiro
Uesugi, Yuki
Tomida, Yutaka
Yoshida, Jun-ichi
author_facet Nagaki, Aiichiro
Uesugi, Yuki
Tomida, Yutaka
Yoshida, Jun-ichi
author_sort Nagaki, Aiichiro
collection PubMed
description The use of FeCl(3) resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO(2), in under a minute.
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spelling pubmed-31702062011-09-13 Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling Nagaki, Aiichiro Uesugi, Yuki Tomida, Yutaka Yoshida, Jun-ichi Beilstein J Org Chem Full Research Paper The use of FeCl(3) resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO(2), in under a minute. Beilstein-Institut 2011-08-02 /pmc/articles/PMC3170206/ /pubmed/21915209 http://dx.doi.org/10.3762/bjoc.7.122 Text en Copyright © 2011, Nagaki et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Nagaki, Aiichiro
Uesugi, Yuki
Tomida, Yutaka
Yoshida, Jun-ichi
Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling
title Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling
title_full Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling
title_fullStr Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling
title_full_unstemmed Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling
title_short Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling
title_sort homocoupling of aryl halides in flow: space integration of lithiation and fecl(3) promoted homocoupling
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170206/
https://www.ncbi.nlm.nih.gov/pubmed/21915209
http://dx.doi.org/10.3762/bjoc.7.122
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AT tomidayutaka homocouplingofarylhalidesinflowspaceintegrationoflithiationandfecl3promotedhomocoupling
AT yoshidajunichi homocouplingofarylhalidesinflowspaceintegrationoflithiationandfecl3promotedhomocoupling

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