Hepatocyte Growth Factor (HGF) Inhibits Collagen I and IV Synthesis in Hepatic Stellate Cells by miRNA-29 Induction

BACKGROUND: In chronic liver disease, hepatic stellate cells (HSC) transdifferentiate into myofibroblasts, promoting extracellular matrix (ECM) synthesis and deposition. Stimulation of HSC by transforming growth factor-β (TGF-β) is a crucial event in liver fibrogenesis due to its impact on myofibrob...

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Detalles Bibliográficos
Autores principales: Kwiecinski, Monika, Noetel, Andrea, Elfimova, Natalia, Trebicka, Jonel, Schievenbusch, Stephanie, Strack, Ingo, Molnar, Levente, von Brandenstein, Melanie, Töx, Ulrich, Nischt, Roswitha, Coutelle, Oliver, Dienes, Hans Peter, Odenthal, Margarete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170366/
https://www.ncbi.nlm.nih.gov/pubmed/21931759
http://dx.doi.org/10.1371/journal.pone.0024568

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