Cargando…

Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a(+/−) mouse model

Accentuated right ventricular (RV) gradients in action potential duration (APD) have been implicated in the arrhythmogenicity observed in Brugada syndrome in studies assuming that ventricular effective refractory periods (VERPs) vary in concert with APDs. The present experiments use a genetically mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin, Claire A., Grace, Andrew A., Huang, Christopher L.-H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Cardiovascular Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170477/ https://www.ncbi.nlm.nih.gov/pubmed/21779762 http://dx.doi.org/10.1007/s00424-011-0989-3

Ejemplares similares

Mouse Models of SCN5A-Related Cardiac Arrhythmias
por: Derangeon, Mickael, et al.
Publicado: (2012)

Delayed conduction and its implications in murine Scn5a(+/−) hearts: independent and interacting effects of genotype, age, and sex
por: Jeevaratnam, Kamalan, et al.
Publicado: (2010)

Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/− mouse model
por: Martin, Claire A., et al.
Publicado: (2011)

Atrial arrhythmogenicity in aged Scn5a+/∆KPQ mice modeling long QT type 3 syndrome and its relationship to Na(+) channel expression and cardiac conduction
por: Guzadhur, Laila, et al.
Publicado: (2010)

Atrial arrhythmogenesis in wild-type and Scn5a+/Δ murine hearts modelling LQT3 syndrome
por: Dautova, Yana, et al.
Publicado: (2009)

Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/− hearts
por: Zhang, Y, et al.
Publicado: (2014)

Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome
por: Wu, Jingjing, et al.
Publicado: (2012)

Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties
por: Hakim, P, et al.
Publicado: (2010)

Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models
por: Huang, Christopher L.-H., et al.
Publicado: (2012)

Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2020)

Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes
por: Yagihara, Nobue, et al.
Publicado: (2016)

Meta-Analysis of Risk Stratification of SCN5A With Brugada Syndrome: Is SCN5A Always a Marker of Low Risk?
por: Yang, Yihan, et al.
Publicado: (2019)

Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/−) hearts
por: Matthews, Gareth D K, et al.
Publicado: (2013)

SCN5A Variants: Association With Cardiac Disorders
por: Li, Wenjia, et al.
Publicado: (2018)

In vivo studies of Scn5a+/− mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities
por: Martin, Claire A., et al.
Publicado: (2010)

miR-190a-5p Partially Represses the Abnormal Electrical Activity of SCN3B in Cardiac Arrhythmias by Downregulation of IL-2
por: Li, Qianqian, et al.
Publicado: (2022)

Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy
por: Freyermuth, Fernande, et al.
Publicado: (2016)

CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias
por: Pang, Paul D., et al.
Publicado: (2018)

Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in ΔKPQ Scn5a murine hearts modelling human long QT 3 syndrome
por: Thomas, G, et al.
Publicado: (2008)

Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders
por: Plastiras, Sotiris C, et al.
Publicado: (2021)

Disease Modifiers of Inherited SCN5A Channelopathy
por: Verkerk, Arie O., et al.
Publicado: (2018)

Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome
por: Renard, Estelle, et al.
Publicado: (2023)

Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias
por: Nakanishi, Hiroyuki, et al.
Publicado: (2019)

Reduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice
por: Martin, Claire A., et al.
Publicado: (2012)

In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant
por: Doisne, Nicolas, et al.
Publicado: (2021)

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts
por: Salvage, S C, et al.
Publicado: (2015)

Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model
por: Martin, Claire A., et al.
Publicado: (2011)

Functional interaction of Junctophilin 2 with small‐ conductance Ca(2+)‐activated potassium channel subtype 2(SK2) in mouse cardiac myocytes
por: Fan, H. K., et al.
Publicado: (2017)

Case Report: Family Curse: An SCN5A Mutation, c.611C>A, p.A204E Associated With a Family History of Dilated Cardiomyopathy and Arrhythmia
por: Huang, Wen, et al.
Publicado: (2022)

Corrigendum: Case Report: Family Curse: An SCN5A Mutation, c.611C>A, p.A204E Associated With a Family History of Dilated Cardiomyopathy and Arrhythmia
por: Huang, Wen, et al.
Publicado: (2022)

A Reproducible Protocol to Assess Arrhythmia Vulnerability in silico: Pacing at the End of the Effective Refractory Period
por: Azzolin, Luca, et al.
Publicado: (2021)

Theoretical Models and Computational Analysis of Action Potential Dispersion for Cardiac Arrhythmia Risk Stratification
por: Avula, Uma Mahesh R., et al.
Publicado: (2021)

Cardiomyocyte Deletion of Bmal1 Exacerbates QT- and RR-Interval Prolongation in Scn5a(+/ΔKPQ) Mice
por: Schroder, Elizabeth A., et al.
Publicado: (2021)

Sustained conduction of vasomotor responses in rat mesenteric arteries in a two‐compartment in vitro set‐up
por: Palao, T., et al.
Publicado: (2018)

Severe Bradycardia Increases the Incidence and Severity of Torsade de Pointes Arrhythmias by Augmenting Preexistent Spatial Dispersion of Repolarization in the CAVB Dog Model
por: van Weperen, Valerie Y. H., et al.
Publicado: (2021)

The effect of ionizing radiation through cardiac stereotactic body radiation therapy on myocardial tissue for refractory ventricular arrhythmias: A review
por: Whitaker, John, et al.
Publicado: (2022)

Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome
por: Hothi, Sandeep S., et al.
Publicado: (2009)

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk‐related rat model of heart failure with preserved ejection fraction
por: Miranda‐Silva, Daniela, et al.
Publicado: (2019)

EGCG Alleviates Obesity-Induced Myocardial Fibrosis in Rats by Enhancing Expression of SCN5A
por: Yi, Haoan, et al.
Publicado: (2022)

Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells
por: Chen, Yating, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_al92lsambmcembesnp9ujurr6d