Therapeutic promise and challenges of targeting DLL4/NOTCH1

DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development o...

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Detalles Bibliográficos
Autor principal: Yan, Minhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170613/
https://www.ncbi.nlm.nih.gov/pubmed/21824400
http://dx.doi.org/10.1186/2045-824X-3-17
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author Yan, Minhong
author_facet Yan, Minhong
author_sort Yan, Minhong
collection PubMed
description DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors (GSIs) might offer insights into how to safely harness this important signaling pathway.
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spelling pubmed-31706132011-09-11 Therapeutic promise and challenges of targeting DLL4/NOTCH1 Yan, Minhong Vasc Cell Review DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors (GSIs) might offer insights into how to safely harness this important signaling pathway. BioMed Central 2011-08-08 /pmc/articles/PMC3170613/ /pubmed/21824400 http://dx.doi.org/10.1186/2045-824X-3-17 Text en Copyright ©2011 Yan; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Yan, Minhong
Therapeutic promise and challenges of targeting DLL4/NOTCH1
title Therapeutic promise and challenges of targeting DLL4/NOTCH1
title_full Therapeutic promise and challenges of targeting DLL4/NOTCH1
title_fullStr Therapeutic promise and challenges of targeting DLL4/NOTCH1
title_full_unstemmed Therapeutic promise and challenges of targeting DLL4/NOTCH1
title_short Therapeutic promise and challenges of targeting DLL4/NOTCH1
title_sort therapeutic promise and challenges of targeting dll4/notch1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170613/
https://www.ncbi.nlm.nih.gov/pubmed/21824400
http://dx.doi.org/10.1186/2045-824X-3-17
work_keys_str_mv AT yanminhong therapeuticpromiseandchallengesoftargetingdll4notch1

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