Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors

BACKGROUND: RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. The RASSF1 locus contains two CpG islands (A and C) and generates seven transcripts (RASSF1A-RASSF1G) by differential promoter...

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Detalles Bibliográficos
Autores principales: Malpeli, Giorgio, Amato, Eliana, Dandrea, Mario, Fumagalli, Caterina, Debattisti, Valentina, Boninsegna, Letizia, Pelosi, Giuseppe, Falconi, Massimo, Scarpa, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170651/
https://www.ncbi.nlm.nih.gov/pubmed/21838870
http://dx.doi.org/10.1186/1471-2407-11-351

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