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Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma

Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic...

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Autor principal: Kondo, Fukuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170744/
https://www.ncbi.nlm.nih.gov/pubmed/22007311
http://dx.doi.org/10.4061/2011/241652
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author Kondo, Fukuo
author_facet Kondo, Fukuo
author_sort Kondo, Fukuo
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description Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) the amount of fibrous components of stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation. Knowledge of stromal invasion is also useful for a better understanding of the vasculature (hypovascular HCCs) and histological features (fatty change) of early HCCs. Invasion of preexisting arteries and portal veins causes hypo-vascularity of HCCs. Further, hypovascularity causes fatty change as a hypoxic change of cancer tissues.
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spelling pubmed-31707442011-10-17 Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma Kondo, Fukuo Int J Hepatol Review Article Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) the amount of fibrous components of stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation. Knowledge of stromal invasion is also useful for a better understanding of the vasculature (hypovascular HCCs) and histological features (fatty change) of early HCCs. Invasion of preexisting arteries and portal veins causes hypo-vascularity of HCCs. Further, hypovascularity causes fatty change as a hypoxic change of cancer tissues. SAGE-Hindawi Access to Research 2011 2011-06-08 /pmc/articles/PMC3170744/ /pubmed/22007311 http://dx.doi.org/10.4061/2011/241652 Text en Copyright © 2011 Fukuo Kondo. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kondo, Fukuo
Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
title Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
title_full Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
title_fullStr Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
title_full_unstemmed Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
title_short Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
title_sort assessment of stromal invasion for correct histological diagnosis of early hepatocellular carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170744/
https://www.ncbi.nlm.nih.gov/pubmed/22007311
http://dx.doi.org/10.4061/2011/241652
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