Cargando…
Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170744/ https://www.ncbi.nlm.nih.gov/pubmed/22007311 http://dx.doi.org/10.4061/2011/241652 |
_version_ | 1782211667379093504 |
---|---|
author | Kondo, Fukuo |
author_facet | Kondo, Fukuo |
author_sort | Kondo, Fukuo |
collection | PubMed |
description | Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) the amount of fibrous components of stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation. Knowledge of stromal invasion is also useful for a better understanding of the vasculature (hypovascular HCCs) and histological features (fatty change) of early HCCs. Invasion of preexisting arteries and portal veins causes hypo-vascularity of HCCs. Further, hypovascularity causes fatty change as a hypoxic change of cancer tissues. |
format | Online Article Text |
id | pubmed-3170744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31707442011-10-17 Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma Kondo, Fukuo Int J Hepatol Review Article Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) the amount of fibrous components of stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation. Knowledge of stromal invasion is also useful for a better understanding of the vasculature (hypovascular HCCs) and histological features (fatty change) of early HCCs. Invasion of preexisting arteries and portal veins causes hypo-vascularity of HCCs. Further, hypovascularity causes fatty change as a hypoxic change of cancer tissues. SAGE-Hindawi Access to Research 2011 2011-06-08 /pmc/articles/PMC3170744/ /pubmed/22007311 http://dx.doi.org/10.4061/2011/241652 Text en Copyright © 2011 Fukuo Kondo. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kondo, Fukuo Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma |
title | Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma |
title_full | Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma |
title_fullStr | Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma |
title_full_unstemmed | Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma |
title_short | Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma |
title_sort | assessment of stromal invasion for correct histological diagnosis of early hepatocellular carcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170744/ https://www.ncbi.nlm.nih.gov/pubmed/22007311 http://dx.doi.org/10.4061/2011/241652 |
work_keys_str_mv | AT kondofukuo assessmentofstromalinvasionforcorrecthistologicaldiagnosisofearlyhepatocellularcarcinoma |