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Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a key role in converting intracellular cortisone to physiologically active cortisol, which is implicated in the development of several phenotypes of metabolic syndrome. Inhibition of 11β-HSD1 activity with selective inhibitors has beneficial e...

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Detalles Bibliográficos
Autores principales:	Su, Xiangdong, Vicker, Nigel, Thomas, Mark P, Pradaux-Caggiano, Fabienne, Halem, Heather, Culler, Michael D, Potter, Barry V L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2011
Materias:	Full Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170876/ https://www.ncbi.nlm.nih.gov/pubmed/21608132 http://dx.doi.org/10.1002/cmdc.201100144

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