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Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?
Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals—endocrine disrupting chemicals (EDCs)—has been shown to cause almost consta...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170895/ https://www.ncbi.nlm.nih.gov/pubmed/21918727 http://dx.doi.org/10.4061/2011/342189 |
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author | Hartoft-Nielsen, Marie-Louise Boas, Malene Bliddal, Sofie Rasmussen, Åase Krogh Main, Katharina Feldt-Rasmussen, Ulla |
author_facet | Hartoft-Nielsen, Marie-Louise Boas, Malene Bliddal, Sofie Rasmussen, Åase Krogh Main, Katharina Feldt-Rasmussen, Ulla |
author_sort | Hartoft-Nielsen, Marie-Louise |
collection | PubMed |
description | Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals—endocrine disrupting chemicals (EDCs)—has been shown to cause almost constant exposure of humans with possible harmful influence on health and hormone regulation. EDCs may affect thyroid hormone homeostasis by different mechanisms, and though the effect of each chemical seems scarce, the added effects may cause inappropriate consequences on, for example, foetal neurodevelopment. This paper focuses on thyroid hormone influence on foetal development in relation to the chemicals suspected of thyroid disrupting properties with possible interactions with maternal thyroid homeostasis. Knowledge of the effects is expected to impact the general debate on the use of these chemicals. However, more studies are needed to elucidate the issue, since human studies are scarce. |
format | Online Article Text |
id | pubmed-3170895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31708952011-09-14 Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? Hartoft-Nielsen, Marie-Louise Boas, Malene Bliddal, Sofie Rasmussen, Åase Krogh Main, Katharina Feldt-Rasmussen, Ulla J Thyroid Res Review Article Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals—endocrine disrupting chemicals (EDCs)—has been shown to cause almost constant exposure of humans with possible harmful influence on health and hormone regulation. EDCs may affect thyroid hormone homeostasis by different mechanisms, and though the effect of each chemical seems scarce, the added effects may cause inappropriate consequences on, for example, foetal neurodevelopment. This paper focuses on thyroid hormone influence on foetal development in relation to the chemicals suspected of thyroid disrupting properties with possible interactions with maternal thyroid homeostasis. Knowledge of the effects is expected to impact the general debate on the use of these chemicals. However, more studies are needed to elucidate the issue, since human studies are scarce. SAGE-Hindawi Access to Research 2011 2011-09-11 /pmc/articles/PMC3170895/ /pubmed/21918727 http://dx.doi.org/10.4061/2011/342189 Text en Copyright © 2011 Marie-Louise Hartoft-Nielsen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hartoft-Nielsen, Marie-Louise Boas, Malene Bliddal, Sofie Rasmussen, Åase Krogh Main, Katharina Feldt-Rasmussen, Ulla Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? |
title | Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? |
title_full | Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? |
title_fullStr | Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? |
title_full_unstemmed | Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? |
title_short | Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? |
title_sort | do thyroid disrupting chemicals influence foetal development during pregnancy? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170895/ https://www.ncbi.nlm.nih.gov/pubmed/21918727 http://dx.doi.org/10.4061/2011/342189 |
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