Neurofilamentopathy in Neurodegenerative Diseases

Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration...

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Detalles Bibliográficos
Autores principales: Liu, Quan, Xie, Fang, Alvarado-Diaz, Abdiel, Smith, Mark A, Moreira, Paula I, Zhu, Xiongwei, Perry, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170930/
https://www.ncbi.nlm.nih.gov/pubmed/21915226
http://dx.doi.org/10.2174/1874205X01105010058
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author Liu, Quan
Xie, Fang
Alvarado-Diaz, Abdiel
Smith, Mark A
Moreira, Paula I
Zhu, Xiongwei
Perry, George
author_facet Liu, Quan
Xie, Fang
Alvarado-Diaz, Abdiel
Smith, Mark A
Moreira, Paula I
Zhu, Xiongwei
Perry, George
author_sort Liu, Quan
collection PubMed
description Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented.
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spelling pubmed-31709302011-09-13 Neurofilamentopathy in Neurodegenerative Diseases Liu, Quan Xie, Fang Alvarado-Diaz, Abdiel Smith, Mark A Moreira, Paula I Zhu, Xiongwei Perry, George Open Neurol J Article Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented. Bentham Open 2011-08-26 /pmc/articles/PMC3170930/ /pubmed/21915226 http://dx.doi.org/10.2174/1874205X01105010058 Text en © Liu et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Liu, Quan
Xie, Fang
Alvarado-Diaz, Abdiel
Smith, Mark A
Moreira, Paula I
Zhu, Xiongwei
Perry, George
Neurofilamentopathy in Neurodegenerative Diseases
title Neurofilamentopathy in Neurodegenerative Diseases
title_full Neurofilamentopathy in Neurodegenerative Diseases
title_fullStr Neurofilamentopathy in Neurodegenerative Diseases
title_full_unstemmed Neurofilamentopathy in Neurodegenerative Diseases
title_short Neurofilamentopathy in Neurodegenerative Diseases
title_sort neurofilamentopathy in neurodegenerative diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170930/
https://www.ncbi.nlm.nih.gov/pubmed/21915226
http://dx.doi.org/10.2174/1874205X01105010058
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