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Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary

BACKGROUND: The aim of this study was to determine the impact of lymphadenectomy and nodal metastasis on survival in clinical stage I malignant ovarian germ cell tumour (OGCT). METHODS: Data were obtained from the National Cancer Institute registry from 1988 to 2006. Analyses were performed using St...

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Autores principales: Mahdi, H, Swensen, R E, Hanna, R, Kumar, S, Ali-Fehmi, R, Semaan, A, Tamimi, H, Morris, R T, Munkarah, A R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170967/
https://www.ncbi.nlm.nih.gov/pubmed/21772335
http://dx.doi.org/10.1038/bjc.2011.267
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author Mahdi, H
Swensen, R E
Hanna, R
Kumar, S
Ali-Fehmi, R
Semaan, A
Tamimi, H
Morris, R T
Munkarah, A R
author_facet Mahdi, H
Swensen, R E
Hanna, R
Kumar, S
Ali-Fehmi, R
Semaan, A
Tamimi, H
Morris, R T
Munkarah, A R
author_sort Mahdi, H
collection PubMed
description BACKGROUND: The aim of this study was to determine the impact of lymphadenectomy and nodal metastasis on survival in clinical stage I malignant ovarian germ cell tumour (OGCT). METHODS: Data were obtained from the National Cancer Institute registry from 1988 to 2006. Analyses were performed using Student's t-test, Kaplan–Meier and Cox proportional hazard methods. RESULTS: In all, 1083 patients with OGCT who have undergone surgical treatment and deemed at time of the surgery to have disease clinically confined to the ovary were included 590 (54.48%) had no lymphadenectomy (LND−1) and 493 (45.52%) had lymphadenectomy. Of the 493 patients who had lymphadenectomy, 441 (89.5%) were FIGO surgical stage I (LND+1) and 52 (10.5%) were upstaged to FIGO stage IIIC due to nodal metastasis (LND+3C). The 5-year survival was 96.9% for LND−1, 97.7% for LND+1 and 93.4% for LND+3C (P=0.5). On multivariate analysis, lymphadenectomy was not an independent predictor of survival when controlling for age, histology and race (HR: 1.26, 95% CI: 0.62–2.58, P=0.5). Moreover, the presence of lymph node metastasis had no significant effect on survival (HR: 2.7, 95% CI: 0.67–10.96, P=0.16). CONCLUSION: Neither lymphadenectomy nor lymph node metastasis was an independent predictor of survival in patients with OGCT confined to the ovary. This probably reflects the highly chemosensitive nature of these tumours.
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spelling pubmed-31709672012-08-09 Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary Mahdi, H Swensen, R E Hanna, R Kumar, S Ali-Fehmi, R Semaan, A Tamimi, H Morris, R T Munkarah, A R Br J Cancer Clinical Study BACKGROUND: The aim of this study was to determine the impact of lymphadenectomy and nodal metastasis on survival in clinical stage I malignant ovarian germ cell tumour (OGCT). METHODS: Data were obtained from the National Cancer Institute registry from 1988 to 2006. Analyses were performed using Student's t-test, Kaplan–Meier and Cox proportional hazard methods. RESULTS: In all, 1083 patients with OGCT who have undergone surgical treatment and deemed at time of the surgery to have disease clinically confined to the ovary were included 590 (54.48%) had no lymphadenectomy (LND−1) and 493 (45.52%) had lymphadenectomy. Of the 493 patients who had lymphadenectomy, 441 (89.5%) were FIGO surgical stage I (LND+1) and 52 (10.5%) were upstaged to FIGO stage IIIC due to nodal metastasis (LND+3C). The 5-year survival was 96.9% for LND−1, 97.7% for LND+1 and 93.4% for LND+3C (P=0.5). On multivariate analysis, lymphadenectomy was not an independent predictor of survival when controlling for age, histology and race (HR: 1.26, 95% CI: 0.62–2.58, P=0.5). Moreover, the presence of lymph node metastasis had no significant effect on survival (HR: 2.7, 95% CI: 0.67–10.96, P=0.16). CONCLUSION: Neither lymphadenectomy nor lymph node metastasis was an independent predictor of survival in patients with OGCT confined to the ovary. This probably reflects the highly chemosensitive nature of these tumours. Nature Publishing Group 2011-08-09 2011-07-19 /pmc/articles/PMC3170967/ /pubmed/21772335 http://dx.doi.org/10.1038/bjc.2011.267 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Mahdi, H
Swensen, R E
Hanna, R
Kumar, S
Ali-Fehmi, R
Semaan, A
Tamimi, H
Morris, R T
Munkarah, A R
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
title Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
title_full Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
title_fullStr Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
title_full_unstemmed Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
title_short Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
title_sort prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170967/
https://www.ncbi.nlm.nih.gov/pubmed/21772335
http://dx.doi.org/10.1038/bjc.2011.267
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